Results 11 to 20 of about 22,962 (264)

M1 muscarinic receptor activation mediates cell death in M1-HEK293 cells. [PDF]

PLoS ONE, 2013
HEK293 cells have been used extensively to generate stable cell lines to study G protein-coupled receptors, such as muscarinic acetylcholine receptors (mAChRs).
E Scott Graham, Kerhan K Woo, Miranda Aalderink, Sandie Fry, Jeffrey M Greenwood, Michelle Glass, Mike Dragunow   +6 more
doaj   +4 more sources

Flavonoids with M1 Muscarinic Acetylcholine Receptor Binding Activity [PDF]

Molecules, 2014
Muscarinic acetylcholine receptor-active compounds have potential for the treatment of Alzheimer’s disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at ...
Meyyammai Swaminathan, Chin Fei Chee, Sek Peng Chin, Michael J. C. Buckle, Noorsaadah Abd. Rahman, Stephen W. Doughty, Lip Yong Chung   +6 more
doaj   +3 more sources

Exploring Adjunctive Novel Therapeutic Approach of KarXT (Xanomeline-Trospium Chloride) for Managing Psychotic Symptoms in Patients With Schizophrenia and Alzheimer's Disease. [PDF]

Brain Behav
An overview of the mechanism of action, clinical trials, and classical findings of KarXT for the management of psychotic symptoms in patients with schizophrenia and alzheimer's disease. ABSTRACT Background Acute psychotic symptoms like delusions and hallucinations are of major concern while treating patients with schizophrenia and alzheimer's psychosis,
Kanwal A, Azeem B, Nasir H, Mumtaz F, Ashraf N, Amin MHJ, Kanwal W, Khan BW.   +7 more
europepmc   +2 more sources

Muscarinic acetylcholine receptor M1 mutations causing neurodevelopmental disorder and epilepsy [PDF]

Human Mutation, 2021
De novo rare damaging variants in genes involved in critical developmental pathways, notably regulation of synaptic transmission, have emerged as a frequent cause of neurodevelopmental disorders (NDD). NDD show great locus heterogeneity and for many of the associated genes, there is substantial phenotypic diversity, including epilepsy, intellectual ...
Anna Marcé‐Grau, Xabier Elorza‐Vidal, Carla Pérez‐Rius, Anna Ruiz, Júlia Sala‐Coromina, Elisabet Gabau, Raúl Estévez, Alfons Macaya   +7 more
openalex   +6 more sources

M1 muscarinic acetylcholine receptor in Alzheimer’s disease [PDF]

Neuroscience Bulletin, 2014
The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified.
Jiang, Shangtong, Li, Yanfang, Zhang, Cuilin, Zhao, Yingjun, Bu, Guojun, Xu, Huaxi, Zhang, Yun-Wu   +6 more
openaire   +3 more sources

Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice

Journal of Pharmacological Sciences, 2020
Cholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in the
Keisuke Migita, Akiko Nishimura, Fumihiro Eto, Kohei Koga, Taichi Matsumoto, Kazuki Terada, Shuji Hara, Kenji Honda   +7 more
doaj   +1 more source

Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThe authors evaluated the effect of intrathecal mixture of ginsenosides with neostigmine on formalin-induced nociception and made further clear the role of the spinal muscarinic (M) receptors on the activity of ginsenosides.MethodsA catheter ...
Cheon-Hee Park, Park-Ne Kim, Seong-Heon Lee, Myung Ha Yoon   +3 more
doaj   +1 more source

A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia

Frontiers in Cellular Neuroscience, 2023
Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic receptors in the molecular pathology of schizophrenia. From these data it was proposed that activation of the muscarinic M1 and/or M4 receptor would reduce the ...
Brian Dean, Geor Bakker, Hiroki R. Ueda, Hiroki R. Ueda, Andrew B. Tobin, Alastair Brown, Richard A. A. Kanaan   +6 more
doaj   +1 more source

Targeting the M1 muscarinic acetylcholine receptor in Alzheimer’s disease [PDF]

Neuronal Signaling, 2022
Abstract Alzheimer’s disease (AD) remains a major cause of morbidity and mortality worldwide, and despite extensive research, only a few drugs are available for management of the disease. One strategy has been to up-regulate cholinergic neurotransmission to improve cognitive function, but this approach has dose-limiting adverse effects ...
Dwomoh, Louis, Tejeda, Gonzalo S., Tobin, Andrew B.   +2 more
openaire   +2 more sources

Characterization of the positive and negative inotropic effects of acetylcholine in the human myocardium [PDF]

, 1995
In the human isolated myocardium, acetylcholine (10−9 to 10−3 M) elicited a biphasic inotropic effect (a decrease in the lower and an increase in the higher concentration range) in atrial and a positive inotropic effect in ventricular trabeculae. However,
Bos, E. (Egbert), Du, X.Y. (Xiaoyi), Saxena, P.R. (Pramod Ranjan), Schoemaker, R.G. (Regien)   +3 more
core   +7 more sources