Results 211 to 220 of about 22,962 (264)
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Two affinity states of M1 muscarine receptors
Cellular and Molecular Neurobiology, 19881. The binding of oxotremorine-M to M1 muscarine receptors was examined by measuring competition between the agonist and 3H-pirenzepine, using rabbit hippocampal membranes suspended in 20 mM Tris buffer containing 1 mM Mn2+. 2. Both ligands interacted with a single class of receptors.
L T, Potter +2 more
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M1 and M3 muscarinic receptors
NeuroReport, 1992P-fluoro-hexahydro-sila-difenidol hydrochloride (p-F-HHSiD) (15, 30 micrograms) and pirenzepine (7.5, 15, 30 micrograms), which are highly selective M3 and M1 muscarinic antagonists, respectively, were injected intracerebroventricularly into freely moving rats.
L. IMERI +3 more
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Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens
European Journal of Pharmacology, 1993In the electrically field-stimulated rabbit vas deferens, muscarinic receptor agonists increase twitch-height by actions at postjunctional M2 receptors and decrease twitch-height by actions at prejunctional M1 receptors. In the present studies, in contrast to previous reports, muscarinic receptor agonists primarily decreased twitch-height, produced ...
H E, Shannon +6 more
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Selectivity of oxomemazine for the M1 muscarinic receptors
Archives of Pharmacal Research, 1994The binding characteristics of pirenzepine and oxomemazine to muscarinic receptor were studied to evaluate the selectivity of oxomemazine for the muscarinic receptor subtypes in rat cerebral microsomes. Equilibrium dissociation constant (KD) of (-)-[3H]quinuclidinyl benzilate([3H]QNB) determined from saturation isotherms was 64 pM.
S W, Lee, C W, Woo, J G, Kim
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Stable allosteric binding of m1-toxin to m1 muscarinic receptors.
Molecular Pharmacology, 1993m1-Toxin was found to slow the dissociation of [3H]N-methyl-scopolamine (NMS) and [3H]pirenzepine from m1 muscarinic receptors expressed in the membranes of Chinese hamster ovary cells. When toxin-NMS-receptor complexes were formed in membranes and then dissolved in digitonin, or when these complexes were formed in solution, the toxin completely ...
S I, Max, J S, Liang, L T, Potter
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Action of the muscarinic toxin MT7 on agonist-bound muscarinic M1 receptors.
European Journal of Pharmacology, 2004The muscarinic toxin MT7 is the most selective ligand for the muscarinic M(1) receptors. Previous studies have shown that the toxin interacts with the antagonist-receptor complex and slows the antagonist dissociation rate, possibly by binding to an allosteric site and impeding the access to and egress from the orthosteric binding pocket. In the present
OLIANAS, MARIA CONCETTA +3 more
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Agonist induced phosphorylation of M1 muscarinic receptors
Life Sciences, 199573039
WAUGH, MG, NAHORSKI, S, TOBIN, AB
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Allosteric regulation of cloned m1–m5 muscarinic receptor subtypes
Biochemical Pharmacology, 1991Allosteric regulation of [3H]N-methylscopolamine [( 3H]NMS) and [3H]quinuclidinyl benzilate [( 3H]QNB) dissociation from the m1-m5 muscarinic receptor subtypes was examined in transfected CHO-K1 cells. Half-times of dissociation of [3H]NMS from cell membranes (at 23 degrees) ranged from less than 5 min for the m2 subtype to more than 60 min for the m5 ...
J, Ellis, J, Huyler, M R, Brann
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Astrocytes have both M1 and M2 muscarinic receptor subtypes
Brain Research, 1986In astrocytes, carbachol evoked the turnover of membrane inositol phospholipids prelabelled with [3H]inositol, as revealed by [3H]inositol phosphate accumulation in the presence of 5 mM lithium. This effect was blocked by atropine and by pirenzepine (IC50 2.2 nM and 56 nM, respectively).
S, Murphy, B, Pearce, C, Morrow
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