Results 41 to 50 of about 22,337 (268)
Biomedical Journal, 2017 Background: Spinal cord injury results in disruption of brain-spinal cord fibre connectivity, leading to progressive tissue damage at the site of injury and resultant paralysis of varying degrees.
Cheramadathukudiyil Skaria Paulose +4 more
doaj +1 more source
Antipsychotic-like effect of the muscarinic acetylcholine receptor agonist BuTAC in non-human primates. [PDF]
PLoS ONE, 2015 Cholinergic, muscarinic receptor agonists exhibit functional dopamine antagonism and muscarinic receptors have been suggested as possible future targets for the treatment of schizophrenia and drug abuse. The muscarinic ligand (5R,6R)-6-(3-butylthio-1,2,5-
Maibritt B Andersen +6 more
doaj +1 more source
Cooperative Glutamatergic and Cholinergic Mechanisms Generate Short-Term Modifications of Synaptic Effectiveness in Prepositus Hypoglossi Neurons [PDF]
, 2005 To maintain horizontal eye position on a visual target after a saccade, extraocular motoneurons need a persistent (tonic) neural activity, called "eye-position signal," generated by prepositus hypoglossi (PH) neurons.
Delgado-Garcia, JM +2 more
core +1 more source
Localization of mRNA for the muscarinic M1 receptor in rat stomach
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1996 Cholinergic stimulation of receptors in the oxyntic mucosa results in secretion of mucus, pepsinogen and hydrochloric acid. There has been speculation as to the cellular localization of these receptors in the mucosa and as to which subtype is present in the different cell types.
George Sachs +5 more
openaire +3 more sources
Muscarinic modulation of M and h currents in gerbil spherical bushy cells.
PLoS ONE, 2020 Descending cholinergic fibers innervate the cochlear nucleus. Spherical bushy cells, principal neurons of the anterior part of the ventral cochlear nucleus, are depolarized by cholinergic agonists on two different time scales.
Charlène Gillet +2 more
doaj +1 more source
Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]
, 2015 Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa +3 more
core +1 more source
NeuroImage: Clinical, 2018 Background: It is still unclear which underlying mechanisms are involved in cognitive deficits of psychotic disorders. Pro-cognitive effects of muscarinic M1 receptor agonists suggest alterations in M1 receptor functioning may modulate these symptoms ...
Geor Bakker +7 more
doaj +1 more source
Translational Psychiatry, 2023 Cognitive impairment is a predictor of disability across different neuropsychiatric conditions, and cognitive abilities are also strongly related to educational attainment and indices of life success in the general population.
Sara E. Jones, Philip D. Harvey
doaj +1 more source
Interaction of the Xanthine Nucleotide Binding Goα Mutant with G Protein-coupled Receptors [PDF]
, 1998 We constructed a double mutant version of the α subunit of Go that was regulated by xanthine nucleotides instead of guanine nucleotides (GoαX). We investigated the interaction between GoαX and G protein-coupled receptors in vitro.
Simon, Melvin I., Yu, Bo
core +1 more source
Identification and Characterization of the Rat M1 Muscarinic Receptor Promoter [PDF]
Journal of Neurochemistry, 1999 Abstract : Five subtypes of the muscarinic receptor have been cloned from both the rat and human genomes. Although all five genes have the coding sequences in a single exon, their structures 5′ of the initiation codon are largely uncharacterized, except for the M4 receptor.
Tom I. Bonner, Christoph P. R. Klett
openaire +3 more sources