Results 11 to 20 of about 2,157,910 (222)

Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor [PDF]

Membranes, 2015
The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
doaj   +4 more sources

Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]

Genes, 2013
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven transmembrane helix receptors.
Ockenga, Wymke, Kühne, Sina, Bocksberger, Simone, Banning, Antje, Tikkanen, Ritva, Justus Liebig University Giessen   +5 more
openaire   +6 more sources

Modulation of the M2 Muscarinic Acetylcholine Receptor Activity with Monoclonal Anti-M2 Receptor Antibody Fragments [PDF]

Journal of Biological Chemistry, 2004
Antibodies directed against the second extracellular loop of G protein-coupled receptors are known to have functional activities. From a partial agonist monoclonal antibody directed against the M2 muscarinic receptor, we constructed and produced a single chain variable fragment with high affinity for its target epitope.
Jean-Christophe, Peter, Gerd, Wallukat, Jean, Tugler, Damien, Maurice, Jean-Christophe, Roegel, Jean-Paul, Briand, Johan, Hoebeke   +6 more
openaire   +3 more sources

Expression of muscarinic receptor subtypes and M2-muscarinic inhibition of adenylyl cyclase in lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1995
The relative distribution and absolute quantities of muscarinic receptor subtypes m1, m2, m3, and m4 were determined in membranes of canine trachealis muscle, bronchi, and lung parenchyma by immuno-precipitation with receptor subtype-specific rabbit polyclonal antisera. Additionally, the functional coupling of muscarinic receptors to the inhibition of
C W, Emala, A, Aryana, M A, Levine, R P, Yasuda, S A, Satkus, B B, Wolfe, C A, Hirshman   +6 more
openaire   +3 more sources

Sodium ions allosterically modulate the M2 muscarinic receptor. [PDF]

Sci Rep, 2020
AbstractG protein coupled receptors (GPCRs) play a key role in the vast majority of cellular signal transduction processes. Previous experimental evidence has shown that sodium ion (Na+) allosterically modulate several class A GPCRs and theoretical studies suggested that the same also holds true for muscarinic receptors. Here we examined, using Xenopus
Friedman S, Tauber M, Ben-Chaim Y.
europepmc   +4 more sources

Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice. [PDF]

Psychopharmacology (Berl), 2018
[Carola Romberg-Taylor credited as Carola Romberg] Rationale: Muscarinic acetylcholine receptors are known to play key roles in mediating cognitive processes, and impaired muscarinic cholinergic neurotransmission is associated with normal ageing ...
Romberg C, Bartko S, Wess J, Saksida LM, Bussey TJ.   +4 more
europepmc   +2 more sources

A novel function of the M₂ muscarinic receptor. [PDF]

Trends Pharmacol Sci
The M2 muscarinic receptor (M2R) is a prototypic class A G protein-coupled receptor (GPCR). Interestingly, Fasciani et al. recently identified an internal translation start site within the M2 receptor mRNA, directing the expression of a C-terminal receptor fragment.
Wess J, Liu L.
europepmc   +3 more sources

Activation and dynamic network of the M2 muscarinic receptor. [PDF]

Proc Natl Acad Sci U S A, 2013
G-protein-coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. Although significant advances have been made in structural studies of GPCRs, details of their activation mechanism remain unclear.
Miao Y, Nichols SE, Gasper PM, Metzger VT, McCammon JA.   +4 more
europepmc   +4 more sources

Dualsteric modulators of the M2 muscarinic acetylcholine receptor [PDF]

Journal of Cheminformatics, 2014
G-protein coupled receptors (GPCRs) trigger multiple signal-switching mechanisms like binding of s-arrestin proteins, activation of kinases and G-protein activation [1]. The poor understanding of the conformational changes resulting in these activations is a major challenge for the design of specific GPCR modulating drugs.
Marcel Bermudez, Gerhard Wolber
openaire   +2 more sources

Eosinophil-mediated cholinergic nerve remodeling [PDF]

, 2006
Eosinophils are observed to localize to cholinergic nerves in a variety of inflammatory conditions such as asthma, rhinitis, eosinophilic gastroenteritis, and inflammatory bowel disease, where they are also responsible for the induction of cell ...
McLean, W.G., Anthony G. Fenech, Madziar, B., Madziar, Beata, Durcan, Niamh, Gleich, G.J., Walsh, M., Fenech, Anthony G., McLean, Graham W., Jan Blusztajn, Gerard J. Gleich, Gleich, Gerard J., Niamh Durcan, Hall, Ian P., Beata Madziar, Walsh, Marie-Therese, Hall, I.P., Ian P. Hall, Durcan, N., Costello, Richard W., Richard W. Costello, Marie-Therese Walsh, McGarvey, Lorcan, Costello, R.W., Fenech, A.G., W. Graham McLean, Lorcan McGarvey, Blusztain, J., Blusztajn, Jan   +28 more
core   +1 more source