Results 31 to 40 of about 2,157,910 (222)

Distribution of Muscarinic Acethylcholine Receptors and Related Signal [PDF]

Türk Biyokimya Dergisi, 2006
Muscarinic receptors are members of G protein coupled receptor family. Molecularcloning studies indicate five intronless genes that encode five muscarinic receptorglycoproteins.
Hülya Cabadak
doaj  

Role of K+ Channels in M2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach

Journal of Pharmacological Sciences, 2004
Previously we reported the cholinergic M2 muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach (K. Yokotani, Y. Osumi. J Pharmacol Exp Ther. 1993;264:54–60).
Kumiko Nakamura, Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Keiko Yokotani, Kunihiko Yokotani   +5 more
doaj   +1 more source

Carbachol-Induced Secretion and Homologous Desensitization in Rat Basophilic Leukemia (RBL-2H3) Cells Transfected With Human m2 Muscarinic Acetylcholine Receptors

Journal of Pharmacological Sciences, 2004
Carbachol (CCh) caused a dose-dependent release of β-hexosaminidase and an increase in the production of inositol 1,4,5-trisphosphate (IP3) in RBL-2H3 cells transfected with m2 mAChR cDNA (RBL-m2 cells).
Kazuhiko Oishi, Akihiro Sakurai, Noriyasu Seki, Tomokazu Yoshizumi, Masaatsu K. Uchida   +4 more
doaj   +1 more source

Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. [PDF]

PLoS ONE, 2015
The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity
Franziska Mohr, Eric Krejci, Martina Zimmermann, Jochen Klein   +3 more
doaj   +1 more source

Synthesis of New Cardioselective M2 Muscarinic Receptor Antagonists.

Chemical and Pharmaceutical Bulletin, 2000
A series of 5H-dibenz[b,f]azepine derivatives was prepared and evaluated for binding affinities to muscarinic receptors in vitro. Among them, compound 8 showed a high affinity for human recombinant M2 receptors (Ki=2.6 nm), a low affinity for M4 receptors (39-fold less than for M2 receptors) and a very low affinity for M1 and M3 receptors (119- and 112-
MANDELLI, Giacomina R., MAIORANA, Stefano, TERNI, Patrizia, LAMPERTI, Giuseppina, COLIBRETTI, Maria Luisa, IMBIMBO, Bruno P.   +5 more
openaire   +3 more sources

The N8-Iper agonist of the human muscarinic receptor M2 induces mitochondrial dysfunction in S. cerevisiae

, 2023
Glioblastoma is a malignant human brain tumor of the astrocytic type. The activation of M2 muscarinic receptor (a G protein-coupled receptor, GPCR) by orthosteric agonist Arecaidine Propargyl Ester (APE) and dualsteric agonist N-8-Iper (N8) caused a ...
Antonia Amelina, Angela Cirigliano, Claudia Guerriero, Alessandra Ricelli, Ada Maria Tata, Francesco Mura, Bruno Botta, Teresa Rinaldi, Elena Passarini, Maria Egle De Stefano   +9 more
core  

Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]

, 2006
In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
NOJYO, Yoshiaki, IINO, Satoshi, Y. Nojyo, S. Iino   +3 more
core   +1 more source

Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms.

PLoS ONE, 2010
BackgroundEpidemiological studies link organophosphorus pesticide (OP) exposures to asthma, and we have shown that the OPs chlorpyrifos, diazinon and parathion cause airway hyperreactivity in guinea pigs 24 hr after a single subcutaneous injection.
Becky J Proskocil, Donald A Bruun, Charles M Thompson, Allison D Fryer, Pamela J Lein   +4 more
doaj   +1 more source

RACK1 associates with muscarinic receptors and regulates M(2) receptor trafficking. [PDF]

PLoS ONE, 2010
Receptor internalization from the cell surface occurs through several mechanisms. Some of these mechanisms, such as clathrin coated pits, are well understood.
Cindy L Reiner, Jennifer S McCullar, Rebecca L Kow, Joshua H Le, David R Goodlett, Neil M Nathanson   +5 more
doaj   +1 more source

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source