Results 1 to 10 of about 3,108 (164)

Kinetics of Respiratory Syncytial Virus (RSV) Memphis Strain 37 (M37) Infection in the Respiratory Tract of Newborn Lambs as an RSV Infection Model for Human Infants. [PDF]

PLoS ONE, 2015
Respiratory syncytial virus (RSV) infection in preterm and newborn infants can result in severe bronchiolitis and hospitalization. The lamb lung has several key features conducive to modeling RSV infection in human infants, including susceptibility to ...
Alejandro Larios Mora, Laurent Detalle, Albert Van Geelen, Michael S Davis, Thomas Stohr, Jack M Gallup, Mark R Ackermann   +6 more
doaj   +3 more sources

Phytochemical Profiling of the Halophyte Artemisia fukudo Makino and Its In Vitro Effects on Androgen-Related Pathways Associated With Benign Prostatic Hyperplasia and Alopecia. [PDF]

ChemistryOpen
This study investigated the phytochemical constituents of the halophyte Artemisia fukudo, leading to the isolation and identification of eight compounds characterized by HPLC–DAD and ESI–MS. Importantly, we demonstrate for the first time that jaceidin inhibits 5α‐reductase type 2 and downregulates BPH‐associated proteins (AR, PSA, and PCNA) in prostate
Kim YN, Lee JS, Park MG, Kim YJ, Lee SM, Hwang KH, Yang MH, Kwon BO, Rho JR, Jeong EJ.   +9 more
europepmc   +2 more sources

Formation of CYP3A‐specific metabolites of ibrutinib in vitro is correlated with hepatic CYP3A activity and 4β‐hydroxycholesterol/cholesterol ratio [PDF]

Clinical and Translational Science, 2023
Ibrutinib is an orally administered Bruton's tyrosine kinase inhibitor approved for the treatment of B‐cell malignancies, including chronic lymphocytic leukemia.
Jonghwa Lee, John K. Fallon, Philip C. Smith, Klarissa D. Jackson   +3 more
doaj   +2 more sources

In Silico Evaluation of Potential NDM-1 Inhibitors: An Integrated Docking and Molecular Dynamics Approach [PDF]

Pharmaceuticals
Background/Objectives: Non-fermenting Gram-negative bacteria are resistant to most antibiotics, due to the production of enzymes such as NDM-1. Faced with this challenge, computational methods have become essential for the design of NDM-1 carbapenemase ...
Eduvan Valencia, Mauricio Galvis, Jorge Nisperuza, Vladimir Ballesteros, Fredy Mesa   +4 more
doaj   +2 more sources

Identification of Tetrahydrocannabidiol Metabolites in Human Urine. [PDF]

Drug Test Anal
The detection of Phase I and II metabolites of tetrahydrocannabidiol (H4CBD) in urine after oral ingestion of 25‐mg H4CBD by a volunteer is described. The proposed metabolite structures are based on ESI+ spectra recorded by HPLC‐HRMS and EI spectra after trimethylsilylation recorded by GC–MS.
Schirmer W, Mösch I, Schürch S, Weinmann W.   +3 more
europepmc   +2 more sources

Metabolite-Based Network Pharmacology, Molecular Docking, and Dynamics Simulations to Preliminarily Verify Treating Diabetic Encephalopathy Effect of Kuwanon G. [PDF]

Food Sci Nutr
This study investigates the neuroprotective effects of Kuwanon G (KWG) against diabetic encephalopathy (DE) by characterizing its metabolic profile and therapeutic mechanisms. Using UHPLC‐Q‐TOF‐MS, network pharmacology, molecular docking, and dynamics simulations, 56 metabolites were identified, with nine showing high intestinal absorption and ...
Zhang Y, Zhang S, Niu H, Xie W, Tan Y, Li D, Jin Y.   +6 more
europepmc   +2 more sources

Logo Shape and Color as Drivers of Change in Brand Evaluation and Recognition

Naše Gospodarstvo, 2021
The purpose of the present study was to test whether logo shape and color affect emotional and cognitive response to a new logo. In the explorative part of the study, the effect of the amount of each of the additive primary color on logo perception was ...
Torbarina Matia, Čop Nina Grgurić, Jelenc Lara   +2 more
doaj   +1 more source

The moderating effect of positive word-of-mouth between service quality and customer loyalty in the hospitality sector: A PLS-SEM approach

Journal of Economics and Management, 2022
Aim/purpose – The main objective of this research is to investigate the relationship between service quality and customer loyalty and the moderating effect of positive word-of-mouth on this relationship in the hospitality sector, in North Central Nigeria.
Gontur Silas, Gadi Paul Dung, Bagobiri Esther   +2 more
doaj   +1 more source

Sequential Explanatory Approach: Digital Marketing Implementation Acceleration Programme that Supports the Marketing Performance of Msme Actors

Studia Ekonomiczne i Regionalne, 2023
Because there was a reduced market for their products as a result of the COVID-19 pandemic, several micro, small & medium-sized enterprise (MSME) actors went out of business. One way to boost marketing performance is through digital marketing.
Herawati Andry, Sarwani Sarwani, Sri Lestari Damajanti, Listyawati Liling, Raharja Alda   +4 more
doaj   +1 more source

The Analysis of Masculinity in Advertising: A Qualitative Study Based on Consumer Perceptions

Economics and Business, 2023
The aim of the research was to explore Generations Z’s perceptions of masculinity in advertising and determine which type of masculinity and which masculinity characteristics consumers favor in a masculine character or the advertising message centered ...
Kreicbergs Toms
doaj   +1 more source