Frontiers in Endocrinology, 2021 Metformin is an antidiabetic drug used for the treatment of diabetes and metabolic diseases. Imbalance in the autonomic nervous system (ANS) is associated with metabolic diseases.
Claudinéia Conationi da Silva Franco +22 more
doaj +1 more source
Steady-state energy balance in animal models of obesity and weight loss [PDF]
, 2016 Supported by European Union Seventh Framework Programme (FP7/2007-2013, n°266408 (Full4Health)), the Joint Programme of the Medical Faculty of Norwegian University of Science and Technology (NTNU) and St. Olav’s University Hospital, the Liaison Committee
Barrett, Perry +7 more
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Activation State of the M3 Muscarinic Acetylcholine Receptor Modulates Mammalian Odorant Receptor Signaling [PDF]
Science Signaling, 2011 Crosstalk between neurotransmitter signaling and odorant signaling may enhance the sense of smell.
Yun Rose, Li, Hiroaki, Matsunami
openaire +2 more sources
Enteric dysfunctions in experimental Parkinson's disease: alterations of excitatory cholinergic neurotransmission regulating colonic motility in rats [PDF]
, 2016 Parkinson's disease (PD) is frequently associated with gastrointestinal symptoms, mostly represented by constipation and defecatory dysfunctions.
Al Harraq, Zainab +14 more
core +1 more source
Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells [PDF]
, 1992 We investigated whether the stimulation of human granulosa-lutein cells with muscarinic and nicotinic receptor agonists can cause increases in intracellular free calcium (Ca2+), using Fura-2 microfluorimetry.
Föhr, K. J. +3 more
core +1 more source
Allosteric interactions at the M3 muscarinic acetylcholine receptor
, 2023 The extracellular loops of muscarinic acetylcholine receptors are predicted to play a role in the binding and regulation of allosteric modulators. Furthermore, the sequence of the five subtypes of muscarinic receptors shows a large degree of diversity in this region.
openaire +4 more sources
RORγt antagonist suppresses M3 muscarinic acetylcholine receptor-induced Sjögren's syndrome-like sialadenitis [PDF]
Clinical and Experimental Immunology, 2016 Summary We showed recently that M3 muscarinic acetylcholine receptor (M3R)-reactive CD3+ T cells play a pathogenic role in the development of murine autoimmune sialadenitis (MIS), which mimics Sjögren's syndrome (SS). The aim of this study was to determine the effectiveness and mechanism of action of retinoic acid-related orphan receptor-
M, Tahara +10 more
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Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs [PDF]
, 2016 Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown.
Godin, Antoine G. +4 more
core +1 more source
Calcium Mobilization by Activation of M3/M5 Muscarinic Receptors in the Human Retinoblastoma
Journal of Pharmacological Sciences, 2007 Activation of muscarinic acetylcholine receptors (mAChR) is one of the most important signal transduction pathways in the human body. In this study, we investigated the role of mAChR activation in relation to its subtypes in human retinoblastoma cell ...
Dae-Ran Kim +8 more
doaj +1 more source
Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation [PDF]
, 2007 Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis ...
Kim, Soo-Kyung +3 more
core +1 more source