Results 311 to 320 of about 63,662 (384)

Theranostic Nanoparticles in Prostate Cancer: Disrupting Hypoxia‐Induced Glycolysis by Targeting Hypoxia‐Inducible Factor‐1 Alpha and Downstream Metabolites

Cancer Medicine, Volume 15, Issue 1, January 2026.
The debate in the field of cancer immunotherapy is being changed as nanotechnology breaks the obstacle of cancer immune evasion, target delivery, and systemic toxicity. Esthetically advanced methods that are discussed in this review are nanovaccine, nanoparticle‐enabled checkpoint barrier, cytokine delivery, and T‐cell modulation techniques that ...
Daniel Ejim Uti, Wilson Achu Omang, Esther Ugo Alum, Inalegwu Bawa, Okechukwu Paul‐Chima Ugwu, Ayodeji Oluwafemi Idowu, Item Justin Atangwho, Godwin Eneji Egbung   +7 more
wiley   +1 more source

Subtype-Specific m⁶A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer. [PDF]

Int J Mol Sci
Qattan A, Alkhayal W, Suleman K, Al-Tweigeri T, Tulbah A.   +4 more
europepmc   +1 more source

Ryanodine‐1‐Calstabin Complex Stabilizers in Antidoping Research: Synthesis, Metabolism, and Characterization

ChemPlusChem, Volume 91, Issue 1, January 2026.
RYR‐stabilizers such as S107, JTV‐519, ARM 036, and ARM 210 are emerging doping‐relevant compounds due to their performance‐enhancing effects on leaky skeletal muscle Ca2+ channels. To support proactive antidoping efforts, all four compounds were synthesized and their in vitro metabolism was systematically investigated.
Tristan Möller, Thomas Piper, Mario Thevis   +2 more
wiley   +1 more source

FTO-mediated m6A demethylation of CSF3 suppresses NETosis via downregulation of RLN2 expression in colorectal cancer. [PDF]

Cell Biol Toxicol
Xu J, Zhang J, Li R, Chen S, Duan C, Ma X, Wang X, Liu X, Gu L, Meng K, Li M.   +10 more
europepmc   +1 more source

Melatonin‐engineered MSCs‐exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
• Sleep restriction induces clock rhythmic ferroptosis, leading to skin flap necrosis. • MEXOs deliver USP4 to stabilise ARNTL, restoring circadian rhythm and inhibiting ferroptosis. • The METTL3/YTHDF1 m6A axis up‐regulates USP4 in melatonin‐preconditioned BMSCs.
Xiaoqiong Jiang, Yu Wang, Xuanlong Zhang, Huiming Deng, Liangyu Fang, Chaire Tafadzwa, Jiangnan Yao, Hao Chen, Anqi Ye, Kailiang Zhou, Xiangwei Ling, Jian Xiao   +11 more
wiley   +1 more source

FTO-Eci1 Axis Mediates Exercise-Induced Cardioprotection in Pressure Overload Mice. [PDF]

Biomolecules
Wang J, Chang Z, Lin S, Sha G, Zeng W, Huang Q, Deng Q, Wang S, Hu M, Xia J.   +9 more
europepmc   +1 more source

Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin   +6 more
wiley   +1 more source

Therapy-induced mRNA, rRNA and tRNA methylation alterations confer tolerance phenotype in tumor cells: mechanism and implications. [PDF]

Int J Biol Sci
Jiang A, Liu S, Li Z, Zhang X, Duan M, Li B.   +5 more
europepmc   +1 more source