Results 321 to 330 of about 63,662 (384)

The METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury

Xin Xie, Fang Fang
openalex   +1 more source

The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes [PDF]

Tongguo Shi, Huan Zhang, Yueqiu Chen
openalex   +1 more source

Multi‐omics analysis identifies PUS7 as an immune modulator driving NETs‐mediated macrophage polarization in pancreatic cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
PUS7 reshapes the PDAC immune landscape primarily by inducing NETs, which drive macrophage polarization from M1 to M2, fostering immune suppression and tumour progression. The inhibitory effects of S428‐1145 and DNase I on pancreatic cancer are mediated through blocking the PUS7/NETs/M2 macrophage pathway.
Jike Fang, Shiye Ruan, Yajie Wang, Yue Chen, Fuxin Huang, Zhongyan Zhang, Chuanzhao Zhang, Baohua Hou, Shanzhou Huang   +8 more
wiley   +1 more source

Comprehensive discovery of m⁶A sites in the human transcriptome at single-molecule resolution. [PDF]

Nat Commun
Kang G, Hwang H, Jeon H, Choi H, Chang HR, Yeo N, Park J, Son N, Jeon E, Lim J, Yun J, Choi W, Jo JY, Kim JS, Park S, Kim YK, Baek D.   +16 more
europepmc   +1 more source

Regulatory mechanism of O‐linked N‐acetylglucosamine protein modification on autophagy in cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
O‐GlcNAcylation serves as a nutrient and stress sensor that dynamically regulates autophagy at multiple stages in cancer cells. It fine‐tunes autophagy initiation, maturation and fusion by modifying key proteins such as ULK1, ATG4B and SNAP‐29. Context‐dependent O‐GlcNAcylation promotes tumour adaptation and therapy resistance via autophagy remodelling.
Yizhan Li, Ling Gao, Shaoming Li, Jingjing Zheng, Keqian Zhi, Wenhao Ren   +5 more
wiley   +1 more source

Characterization of m⁶A-regulated targets and immune cells in dental caries: insights from multi-omics analysis. [PDF]

Eur J Med Res
Zhou X, Shi C, Li K, Yao S, Ma L, Mao Y, Jiang L, Jiao P.   +7 more
europepmc   +1 more source

ZFHX3 acts as a tumor suppressor in prostate cancer by targeting FTO-mediated m6A demethylation [PDF]

Qingxia Hu, Junling Yin, Sijie Zhao, Yibo Wang, Ruxue Shi, Keqiang Yan, Shuhong Huang   +6 more
openalex   +1 more source

Diabetic Kidney Disease Progression Alleviated in Mice by ALKBH5‐Mediated UC‐MSCs‐Derived Exosomes That Inhibit TRAF6 m6A Modification and Promote M2 Macrophage Polarisation

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
ALKBH5‐modified UC‐MSCs‐derived exosomes (OE‐ALKBH5 Exo) inhibit the expression of M1 markers (iNOS, IL‐1β, TNF‐α, CD86) and enhance the expression of M2 markers (IL‐10, Arg‐1, CD206) by inhibiting the m6A methylation of TRAF6 and reducing its protein level and stability, thereby promoting M2 polarisation and alleviating the progression of DKD ...
Lei Li, Hongmei Liu, Huanhuan Wang, Yu Mao, Lige Song, Zhiqiang Kang   +5 more
wiley   +1 more source

METTL16 Inhibits Lens Epithelial Cells Function in Diabetic Cataract via m6A-Modified DKK1-Mediated Wnt/β-Catenin Signaling. [PDF]

Invest Ophthalmol Vis Sci
Zhang B, Sun Y, Jiang X, Hu Z, Wang X, Zhao YE.   +5 more
europepmc   +1 more source

Circular RNAs as Biomarkers and Therapeutic Targets in Diabetic Cardiovascular Complications

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
This graphic abstract elaborates on the recent mechanism of circular RNAs (circRNAs) in the pathogenesis, diagnosis and treatment of diabetic cardiovascular complications. Diabetes mellitus induces oxidative/inflammatory stress, followed by endothelial dysfunction and leads to micro‐/macro‐vascular complications.
Shreya Singh Beniwal, Yujin Jeong, Akash Rawat, Mahmoud Einieh, Kashyapi Patil, Rafael Everton Assunção Ribeiro da Costa, Pulkit Saini, Kamal Yousef Ghazal, Abhijeet Kumar, Ayush Dwivedi, Anuja Anil Mandavkar   +10 more
wiley   +1 more source