Results 361 to 370 of about 63,662 (384)

Site-specific m6A editing

Nature Chemical Biology, 2019
The N6-methyladenosine modification on RNA affects almost all steps of RNA metabolism. A new approach, using the CRISPR-based technology to modulate m6A level in mRNA, enables direct functional interrogation of site-specific m6A.
Jiangbo Wei, Chuan He
openaire   +2 more sources

m6A nuclear condensates support AML

Nature Reviews Molecular Cell Biology, 2021
Nuclear condensates of m6A-methylated mRNAs with their ‘reader’ YTHDC1 prevent the degradation of acute myeloid leukaemia-promoting mRNAs by the exosome.
openaire   +2 more sources

Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms

Science Translational Medicine, 2022
The role of N6-methyladenosine (m6A) modifications in renal diseases is largely unknown. Here, we characterized the role of N6-adenosine-methyltransferase-like 3 (METTL3), whose expression is elevated in renal tubules in different acute kidney injury ...
Jia-nan Wang, Fang Wang, Jing Ke, Zeng Li, Chuanjie Xu, Qin Yang, Xin Chen, Xiao-yan He, Yuan He, Xiao-guo Suo, Chao Li, Ju-tao Yu, Ling Jiang, W. Ni, Juan Jin, Ming-ming Liu, Wei Shao, Chen Yang, Qian Gong, Hai-yong Chen, Jun Li, Yong-gui Wu, Xiao-ming Meng   +22 more
semanticscholar   +1 more source

Relative Quantification of Residue-Specific m6A RNA Methylation Using m6A-RT-QPCR

2021
Technological advances in high-throughput sequencing in combination with antibody enrichment and/or induced nucleotide-specific chemical modifications have accelerated the mapping of epitranscriptomic modifications. However, site-specific detection and quantification of m6A are still technically challenging.
Ane, Olazagoitia-Garmendia, Ainara, Castellanos-Rubio   +1 more
openaire   +2 more sources

The m6A reader ECT1 drives mRNA sequestration to dampen salicylic acid-dependent stress responses in Arabidopsis.

The Plant Cell, 2023
N 6-methyladenosine (m6A) is a common epitranscriptional mRNA modification in eukaryotes. Thirteen putative m6A readers, mostly annotated as EVOLUTIONARILY CONSERVED C-TERMINAL REGION (ECT) proteins, have been identified in Arabidopsis (Arabidopsis ...
K. Lee, Kaiwei Liu, Eun Yu Kim, L. Medina-Puche, Hai-xin Dong, Minghui Di, Rahul Mohan Singh, Mengping Li, Shan Qi, Zhuoling Meng, Jungnam Cho, Heng Zhang, Rosa Lozano-Durán, Chanhong Kim   +13 more
semanticscholar   +1 more source

RNA m6A methylation regulators in sepsis

Molecular and Cellular Biochemistry, 2023
N6-methyladenosine (m6A) modification is a class of epitope modifications that has received significant attention in recent years, particularly in relation to its role in various diseases, including sepsis. Epigenetic research has increasingly focused on m6A modifications, which is influenced by the dynamic regulation of three protein types: ‟Writers" (
Lin, Zhu, Hairong, Zhang, Xiaoyu, Zhang, Lei, Xia   +3 more
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N6‐methyladenosine (m6A) Modification in Preeclampsia

Reproductive Sciences, 2023
Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang, Ziyan Jiang, Nana Yang, Zhiping Ge, Qing Zuo, Shiyun Huang, Lizhou Sun   +6 more
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The roles and implications of RNA m6A modification in cancer

Nature Reviews Clinical Oncology, 2023
Xiaolan Deng, Y. Qing, D. Horne, Huilin Huang, Jianjun Chen   +4 more
semanticscholar   +1 more source

m6A mRNA modification regulates mammalian spermatogenesis

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
Mammalian spermatogenesis is a highly specialized differentiation process involving precise regulatory mechanisms at the transcriptional, posttranscriptional, and translational levels. Emerging evidence has shown that N6-methyladenosine (m6A), an epitranscriptomic regulator of gene expression, can influence pre-mRNA splicing, mRNA export, turnover, and
Zhen, Lin, Ming-Han, Tong
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Viral RNA in an m6A disguise

Nature Microbiology, 2020
N6-methyladenosine (m6A) is a widespread modifcation on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways.
openaire   +2 more sources