Results 271 to 280 of about 24,574 (283)
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The potential role of m6A RNA methylation in diabetic retinopathy
Experimental Eye Research, 2021Diabetic retinopathy (DR), a major microvascular complication of diabetes, affects most diabetic individuals and has become the leading cause of vision loss. Metabolic memory associated with diabetes retains the risk of disease occurrence even after the termination of glycemic insult.
Nidhi Kumari +3 more
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Role of m6A RNA Methylation in Ischemic Stroke
Molecular NeurobiologyIschemic stroke is a prominent contributor to global morbidity and mortality rates. The intricate and diverse mechanisms underlying ischemia-reperfusion injury remain poorly comprehended. RNA methylation, an emerging epigenetic modification, plays a crucial role in regulating numerous biological processes, including immunity, DNA damage response ...
Yayun Xu, Wenqiang Liu, Lijie Ren
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m6A RNA Methylation and Implications for Hepatic Lipid Metabolism
DNA and Cell BiologyThis review presents a summary of recent progress in research on the N6-methyladenosine (m6A) modification and regulatory roles in hepatic lipid metabolism. As the most abundant internal modification of eukaryotic RNA, the m6A modification is a dynamic and reversible process of the m6A enzyme system, which includes writers, erasers, and readers.
Xinyue Ming +5 more
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RNA m6A methylation at the juxtaposition of apoptosis and RNA therapeutics
Trends in Cell BiologyTargeting RNA m6A marks in apoptosis-related transcripts holds promise for RNA therapeutics. However, pathway-specific RNA m6A sites on pro- or antiapoptotic transcripts have not been fully unveiled, let alone characterized. This article summarizes the current knowledge and gaps in the cellular response modulated by apoptotic stimulus-specific RNA m6A ...
Bünyamin Akgül +2 more
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m6A RNA methylation: The latent string-puller in fibrosis
Life SciencesFibrosis is a pathological phenomenon characterized by the aberrant accumulation of extracellular matrix (ECM) in tissues. Fibrosis is a universally age-related disease involving that many organs and is the final stage of many chronic inflammatory diseases, which often threaten the patient's health.
Xinglan, He +7 more
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RNA m6A methylation in psychiatric disorders.
EC psychology and psychiatryThis comprehensive review introduces the features of m6A modification and its role in neuropsychiatric disorders. The research findings suggest that m6A modifications and their regulators play a critical role in the occurrence and development of major psychiatric disorders, especially Alzheimer's disease, affecting synaptic protein synthesis, subtype ...
Qiao, Mao +7 more
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RNA Modification by m6A Methylation in Cardiovascular Disease
2021Cardiovascular disease is currently the leading cause of death worldwide, and its underlying regulatory mechanisms remain largely unknown. N6-Methyladenosine (m6A) RNA methylation is an epigenetic modification involved in the splicing, nuclear export, translational regulation, and degradation of RNA.
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RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension
Hypertension Researchm6A (N6‑methyladenosine) is the most common and abundant apparent modification in mRNA of eukaryotes. The modification of m6A is regulated dynamically and reversibly by methyltransferase (writer), demethylase (eraser), and binding protein (reader).
Zhe, Wang +9 more
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m6A RNA methylation in heart development, regeneration and disease
Hypertension Research, 2021Arumugam, Paramasivam +1 more
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M6A RNA methylation is integral for endothelial plasticity
Atherosclerosis, 2023S. Tual-Chalot +6 more
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