Results 181 to 190 of about 29,686,764 (312)

Uncharted territory: assessing antibiotic adverse drug events from walk-in clinics at an academic healthcare system. [PDF]

Antimicrob Steward Healthc Epidemiol
Patel N, Zou M, Nardone E, Thomas R, Zuill A, Shackelford C, Zhang M, Onguti S, Staub M.   +8 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Neurodevelopmental Disorders and the Inverse Metabolic Profile: A Nationwide Propensity-Matched Analysis. [PDF]

Cureus
Luna Landa EM, Arroyo Cisneros M, Erazo G, Pedroza J, Nguefang G.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Mixed-method evaluation of interactive provider dashboards for comparison of outpatient antibiotic prescribing for respiratory and otic conditions in walk-in clinics. [PDF]

Antimicrob Steward Healthc Epidemiol
Percival KM, Dukes KC, Clore GS, Sherlock SH, Ince D, Shaw N, Kinn PM, Weiner L, Kopp C, Sarrazin MV, Livorsi DJ.   +10 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Sustained Improvement in Antibiotic Prescribing Among Private Practice Dentists Following Antibiotic Stewardship Education and Dashboard Implementation. [PDF]

Open Forum Infect Dis
Goff DA, Klesper ME, Dahal K, Sampada F, Sohn M, Guerin J, Allen J, Basali D, Edwards M, Ferguson S, Patel K, Sakamoto F, Souyias J, Shumaker N, Stoner J, Stoner J, Goff D.   +16 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Principal Care Management Codes: An Underutilized Tool to Capture Preoperative Optimization Care. [PDF]

Arthroplast Today
Malhotra RD, Kaul S, Walsh ZA, Call CM, Rana AJ.   +4 more
europepmc   +1 more source