Results 111 to 120 of about 263 (128)
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The Macamide N-3-Methoxybenzyl-Linoleamide Is a Time-Dependent Fatty Acid Amide Hydrolase (FAAH) Inhibitor

Molecular Neurobiology, 2013
The Peruvian plant Lepidium meyenii (Maca) has been shown to possess neuroprotective activity both in vitro and in vivo. Previous studies have also demonstrated the activity of the pentane extract and its macamides, the most representative lipophilic constituents of Maca, in the endocannabinoid system as fatty acid amide hydrolase (FAAH) inhibitors ...
Haifa, Almukadi   +5 more
openaire   +2 more sources

Neuroprotective activity of Macamides on Manganese Chloride Induced Toxicity in U‐87 MG Glioblastoma Cells

The FASEB Journal, 2016
Lepidium meyenii , known as Maca, is a Peruvian herbaceous biennial plant used by indigenous Andean societies as a source of nourishment and healing. Macamides, a distinct class of secondary metabolites which are structurally similar to the endocannabinoids, have neuroprotective effects.
Kuljeet Gugnani   +2 more
openaire   +1 more source

Preparation from Lepidium meyenii Walpers using high-speed countercurrent chromatography and thermal stability of macamides in air at various temperatures

Journal of Pharmaceutical and Biomedical Analysis, 2019
Originally cultivated in the Peruvian Andes, Maca (Lepidium meyenii) is now widely consumed as functional food which is known for its functional characteristic like relieving fatigue and enhancing stamina. Macamides are the unique fatty acids with long-chain and N-benzylamides among the various constituents extracted from Maca.
Jia-Lun, Zhong   +4 more
openaire   +2 more sources

Neuroprotection of macamide in a mouse model of Alzheimer’s disease involves Nrf2 signaling pathway and gut microbiota

European Journal of Pharmacology
The underlying mechanisms of macamide's neuroprotective effects in Alzheimer's disease (AD) were investigated in the paper. Macamides are considered as unique ingredients in maca. Improvement effects and mechanisms of macamide on cognitive impairment have not been revealed.
Nengyin, Xia   +7 more
openaire   +2 more sources

Postharvest Ultrasound‐Assisted Freeze‐Thaw Pretreatment Improves the Drying Efficiency, Physicochemical Properties, and Macamide Biosynthesis of Maca ( Lepidium meyenii )

Journal of Food Science, 2018
Abstract A novel technique of ultrasound‐assisted freeze‐thaw pretreatment (UFP) was developed to improve the drying efficiency of maca and bioactive amide synthesis in maca. The optimal UFP conditions are ultrasonic processing 90 min at 30 °C with 6 freeze‐thaw cycles.
Jin‐Jin Chen   +8 more
openaire   +2 more sources

Therapeutic Efficacy of Macamides on Fragile X Tremor/Ataxia Syndrome (FXT/AS)

The Journal of Pharmacology and Experimental Therapeutics, 2023
Collis Brown   +2 more
openaire   +1 more source

Bio-guided fractionation and metabolomics reveal antiglioma potential of a Lepidium meyenii fraction enriched in macamides and polyunsaturated fatty acids

Lepidium meyenii (maca) is an important food source renowned for its rich profile of bioactive compounds linked to antitumor and antioxidant activities. Herein, bio-guided fractionation and metabolomics were used to investigate L. meyenii potential to produce enriched-fractions with high antiglioma activity.
Fernanda V. Carvalho   +7 more
openaire   +1 more source

Study of the anti-fatigue properties of macamide, a key component in maca water extract, through foodomics and gut microbial genomics

Food Bioscience, 2022
Chang Liu   +7 more
openaire   +1 more source

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