Results 101 to 110 of about 263 (128)

Macamides and their synthetic analogs: Evaluation of in vitro FAAH inhibition

Bioorganic and Medicinal Chemistry, 2013
Maca (Lepidium meyenii), a traditional food crop of the Peruvian Andes is now widely touted as a dietary supplement. Among the various chemical constituents isolated from the plant are a unique series of non-polar, long-chain fatty acid N-benzylamides known as macamides.
Alejandro Pino-Figueroa, Timothy J Maher   +1 more
exaly   +3 more sources

A newly identified polyunsaturated macamide alleviates dextran sulfate sodium-induced colitis in mice

Fitoterapia, 2021
Macamides are a class of bioactive amide alkaloids found only in maca (Lepidium meyenii). Recent studies have shown that macamide-rich extracts possess various biological activities, such as antioxidative, immune-enhancing, and reproductive health-improving activities.
Rui, Zha, Enhui, Ge, Lirong, Guo, Qing, Gao, Qiqi, Lin, Wan, Zhou, Xiaobao, Jin, Weiquan, Xie, Hui, Yin, Tao, Liu   +9 more
openaire   +2 more sources

Antioxidant and antitumoral activities of isolated macamide and macaene fractions from Lepidium meyenii (Maca)

Talanta, 2021
In this paper, a UPLC-ESI-MS was established to analyze macamide and macaene fractions from Lepidium meyenii (Maca). The antioxidant activity of Maca crude extract (MCE), total macamides (TMM) and total macaenes (TME) was evaluated by DPPH radical scavenging, ABTS radical scavenging and reducing power.
Ling, Fu, Jinchao, Wei, Yumei, Gao, Rui, Chen   +3 more
openaire   +2 more sources

The macamide relieves fatigue by acting as inhibitor of inflammatory response in exercising mice: From central to peripheral

European Journal of Pharmacology, 2022
Macamides are the major and unique bioactive compounds of Lepidium meyenii (Walp.) or Maca. N-benzyl-(9Z, 12Z)-octadecadienamide (N-benzyl-linoleamide) is one of the most biologically active macamides with various pharmacological activities - anti-fatigue, neuroprotective, antioxidant, anti-tumoral activities, anti-inflammatory, and analgesic.
Hongkang Zhu, Ruoyong Wang, Hanyi Hua, Yuliang Cheng, Yahui Guo, He Qian, Peng Du   +6 more
openaire   +2 more sources

Pharmacologic Effects of a Synthetic Macamide Analogue (ZYPC) on A549 and HeLa Cells

The FASEB Journal, 2020
Lepidium meyenii L., known as the Maca plant, is acclaimed by the scientific community for its various health benefits in traditional medicine, including prevention of gastritis, depression, and cancer, as well as increasing fertility and improving sexual performance.
Melanie Lam, Alejandro Nico Rondón-Ortiz, Jimena Alexandra Martínez-Málaga, Ana Lucia Gonzales-Urday, Alejandro Pino-Figueroa   +4 more
openaire   +1 more source

Novel macamides from maca ( Lepidium meyenii Walpers) root and their cytotoxicity

Phytochemistry Letters, 2018
Abstract Maca, Lepidium meyenii Walpers (Brassicaceae), contains secondary metabolites, including macamides, which possess many bioactive properties. Two new macamides, namely, N-benzyl-9-oxo-10E,12E-octadecadienamide (3) and N-benzyl-9-oxo-10E,12Z-octadecadienamide (4), were isolated from maca root. In addition, two fatty acid derivatives, 9-oxo-10E,
Chen Xia, Wan-Yi Li
exaly   +2 more sources

Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice

Journal of the Science of Food and Agriculture, 2018
AbstractBACKGROUNDMacamides, the main active components contained in maca, have attracted increasing attention due to their various bioactivities. In this study, crude macamide extract (CME) and purified macamide extract (PME) were prepared by enzyme‐assisted extraction and macroporous resin separation, and the anti‐fatigue effects of CME and PME were ...
Yue Zheng, Wen‐Cheng Zhang, Ze‐Yu Wu, Chuan‐Xiang Fu, Ai‐Ling Hui, Han Gao, Peng‐Peng Chen, Biao Du, Hua‐Wei Zhang   +8 more
openaire   +2 more sources

Analysis of macamides in samples of Maca (Lepidium meyenii) by HPLC‐UV‐MS/MS

Phytochemical Analysis, 2005
AbstractThe macamides are a distinct class of secondary metabolites that have so far been found only in Lepidium meyenii Walp. (Maca). Using HPLC‐UV‐MS/MS, the main macamides have been identified as n‐benzylhexadecanamide, n‐benzyl‐(9Z)‐octadecenamide, n‐benzyl‐(9Z, 12Z)‐octadecadienamide, n‐benzyl‐(9Z, 12Z, 15Z)‐octadecatrienamide and n ...
Megan M, McCollom, Jacquelyn R, Villinski, Kerry L, McPhail, Lyle E, Craker, Stefan, Gafner   +4 more
openaire   +2 more sources

Analysis of Macamides and Macaenes in Maca from Different Origins

Journal of Chromatographic Science
Abstract Macamides and macaenes are two kinds of secondary metabolites in Lepidium meyenii (Maca). Geographical origin has an important effect on accumulation of active components in Maca. Hence, it is feasible to differentiate Maca from different origins according to the type and content of macamides and macaenes.
Suitong Yan, Yongyan Sun, Yan Xu, Yanni Dong, Huixing Mou, Fan Wang, Rui Chen   +6 more
openaire   +2 more sources

Simultaneous Analysis of Macamides in Maca (Lepidium meyenii) with Different Drying Process by Liquid Chromatography Tandem Mass Spectrometry

Food Analytical Methods, 2015
Macamides with benzylalkylamides structure are a group of characteristic constituents isolated from functional food Maca (Lepidium meyenii Walp.). Previous study demonstrated that macamides are secondary amides, the accumulation of which is associated with drying process.
Yu Pan, Ji Zhang, Yuanzhong Wang
exaly   +2 more sources