Results 81 to 90 of about 42,805 (306)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Flavour in "Pedro Ximénez" grape musts subjected to maceration processes
, 2015 Crushed grapes of Vitis vinifera cv. Pedro Ximenez were macerated at 10, 15 and 25°C for 4, 16, 24 and 48 hours. The musts obtained after pressing were used for the determination of higher alcohols, esters and terpene compounds.
Moyano, L. +3 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Acta Scientiarum: Biological Sciences, 2008 Laboratórios de Zoologia em Instituições de Pesquisa e Ensino têmdemonstrado grande demanda por peças anatômicas para utilização em aulas práticas. No entanto, embora a bibliografia voltada para este tema não seja escassa, são raras as análises das ...
Márcio José da Silveira +2 more
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Pre-fermentation maceration of pinot noir wine
, 1993 Two pre-fermentation treatments were investigated in Pinot noir (Vitis vinifera L.) wines. The effects of cold maceration and carbonic maceration on the wines' composition, colour parameters and sensory properties were examined.
Goldsworthy, Sharon A.
core
Technical and economic evaluation of maceration of red grapes
, 2013 For red wines, the phase of maceration is fundamental as it affects important features such as colour, aroma and flavour. For wines for everyday consumption these features must provide an easily drinkable product with a good quality basis that is ...
FRISO, DARIO, C. Caprara, F. Pezzi
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Effect of Maceration Conditions on Chemical Composition and Colour Characteristics of Merlot Wines
, 2015 Due to their complex composition, Merlot cultivar red grapes were subjected to maceration-fermentation as an important stage for the natural pigments and aroma compounds extraction.
Carmen Pop +4 more
core +1 more source