Results 81 to 90 of about 4,445 (267)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Ingenieria Industrial, 2010 En este artículo se recurre a métodos estadísticos para analizar la maquinabilidad de mate-riales compuestos de matriz termoplástica. Se aplicará el análisis ANOVA para cuantificar la influencia de los parámetros funcionales de corte sobre la evolución ...
Francisco Mata, J. Paulo Davim
doaj
Finish turning of toolox 33 to improve machining parameters with different nose radius tools
European Mechanical ScienceTurning, the most widely used machining process in manufacturing, continues to maintain its popularity today. Given its ongoing relevance, evaluating machinability in turning operations remains critical.
Rüstem Binali +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
European Mechanical ScienceIn this study, the affects of machining parameters on surface roughness and cutting forces during machining on a conventional lathe of AA 6082 aluminum alloy, which is widely utilized in automotive, manufacturing, and aerospace sectors, were investigated.
Ayşe Sena Yamaner, Bahar Sayın Kul
doaj +1 more source
Medžiagotyra, 2019 A co-continuous ceramic composite (C4) was manufactured by gravity infiltration. The effect of varying machining parameters namely, speed, feed and depth of cut during end milling of C4, on the multi-responses of surface roughness, tool wear and depth of
Prasanth ACHUTHAMENON SYLAJAKUMARI +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Bulletin of the Polish Academy of Sciences Technical Sciences, 2018 Modeling interactions between features improves the performance of machine learning solutions in many domains (e.g. recommender systems or sentiment analysis). In this paper, we introduce Exponential Machines (ExM), a predictor that models all interactions of every order.
A. Novikov, M. Trofimov, I. Oseledets
openaire +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source