Results 71 to 80 of about 4,445 (267)

AISI 1.2738 Çeliğinin Elektro-Erozyon Tezgahında Grafit Elektrot ile İşlenmesinde İşleme Parametrelerinin Yüzey Pürüzlülüğü Üzerine Etkisinin İncelenmesi

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2018
Bu çalışmada, AISI 1.2738malzemenin farklı işleme parametrelerinde elektro erozyon tezgahında bakır vegrafit elektrot ile aşındırma işlemi gerçekleştirilmiştir. Kullanılan aşındırmaparametreleri yapılan ön deneyler sonrasında üç farklı vurum süresi (100,
Engin Nas, Kudbeddin Argun, Erman Zurnacı   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effect of Dry and Wet Machining Environments on Surface Quality of Al6061 Using Particle Swarm Optimization (PSO)

Engineering Proceedings
Aluminum, one of the most abundant metals found on our planet, plays a crucial role in manufacturing as it is lightweight and resistant to corrosion and has excellent machinability.
Mahendra U. Gaikwad, Avinash A. Somatkar, Mahendra Gadge, Himadri Majumder, Abhishek M. Shinde, Atharv V. Lohakare   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Machine consciousness

Scholarpedia, 2005
The work from several laboratories on the modeling of consciousness is reviewed. This ranges, on one hand, from purely functional models where behavior is important and leads to an attribution of consciousness to, on the other hand, material work closely derived from the information about the anatomy of the brain. At the functional end of the spectrum,
openaire   +2 more sources

Comprehensive Analysis of Microstructure and Mechanical, Operational, and Technological Properties of AISI 321 Austenitic Stainless Steel at Electron Beam Freeform Fabrication

Construction Materials
The aim of this study was to investigate microstructure and the mechanical and operational characteristics of thick and thin walls 3D-built by electron beam additive manufacturing (EBAM).
Sergey V. Panin, Mengxu Qi, Dmitry Yu. Stepanov, Mikhail V. Burkov, Valery E. Rubtsov, Yury V. Kushnarev, Igor Yu. Litovchenko   +6 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Giry and the Machine

Electronic Notes in Theoretical Computer Science, 2016
AbstractWe present a general method – the Machine – to analyse and characterise in finitary terms natural transformations between well-known functors in the category Pol of Polish spaces. The method relies on a detailed analysis of the structure of Pol and a small set of categorical conditions on the domain and codomain functors.
Fredrik Dahlqvist, Vincent Danos, Ilias Garnier   +2 more
openaire   +3 more sources

Determination of Optimum Machining Parameters in Machining Rene 41 Superalloy Depending on Cutting Speed [PDF]

E3S Web of Conferences
Rene 41 superalloy developed to withstand severe mechanical stresses and high temperature operation, and are widely used in aircraft and space vehicles, especially nickel-based ones, due to their high corrosion resistance.
Altin Abdullah, Altin Muhammed Cihat, Altin Hilal, Altin Tuğba   +3 more
doaj   +1 more source