Results 61 to 70 of about 1,297,449 (284)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

High precision manufacturing method of multi-thread worm wheel using 5-axis machining center

open access: yesNihon Kikai Gakkai ronbunshu, 2019
In recent years, the speeding up of a rotary table using a worm gear pair has been required. In order to perform the speeding up of a rotary table, the multi-thread worm wheel is adopted in some cases. When a hob tool for cutting a worm wheel is likewise
Shigenori HAMADA   +2 more
doaj   +1 more source

Identification of a 7-phase claw-pole starter-alternator for a micro-hybrid automotive application [PDF]

open access: yes, 2008
This paper deals with the identification of a new high power starter-alternator system, using both: a Finite Element Method (FEM) modeling and an experimental vector control.
BOUSCAYROL, Alain   +6 more
core   +6 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Development of a mechanical element that changes the shape and rigidity by vacuum pressure

open access: yesNihon Kikai Gakkai ronbunshu, 2019
The passive mechanical element that can change the stiffness by using particle jamming has been used for soft robots. The mechanical element can keep the shape by decreasing the internal air pressure, however, is not able to transform the shape by itself.
Shinsaku OTSUKA, Takashi MITSUDA
doaj   +1 more source

SFO: A Toolbox for Submodular Function Optimization [PDF]

open access: yes, 2010
In recent years, a fundamental problem structure has emerged as very useful in a variety of machine learning applications: Submodularity is an intuitive diminishing returns property, stating that adding an element to a smaller set helps more than adding ...
Krause, Andreas
core   +1 more source

Influence of the amount of permanent-magnet material in fractional-slot permanent-magnet synchronous machines [PDF]

open access: yes, 2014
The efficiency of permanent-magnet (PM) synchronous machines with outer rotor and concentrated windings is investigated as a function of the mass of magnets used, keeping the power, volume, and mechanical air-gap thickness constant. In order to be useful
Sergeant, Peter, Van den Bossche, Alex
core   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Development of a solid bolt/nut model utilized in 3D-FE structural analysis for bolted joints

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
This study aims to develop a solid bolt/nut model utilized in 3D-FE analysis for the strength design of mechanical structures with bolted joints to obtain the internal forces and the bending moment acting on the bolt/nut assembly.
Masaya HAGIWARA, Tomohiro KAWAMURA
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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