Results 71 to 80 of about 189,037 (316)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Control Method for Output Speed during Velocity Ratio Change under High Rotational Speed Using an Uninterrupted Transmission System

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Transmissions that can change their velocity ratio are used in various mechanical devices to achieve a wide range of torques or speeds. For machines with transmissions, such as transportation vehicles, it is required to keep the output speed or the ...
Jungchul KANG, Masaharu KOMORI, Shuai ZHANG, Koki SUGIYAMA   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The significance of air pockets for modelling thermal errors of machine tools

, 2013
It is well known, especially with the prevalence of compensation for geometric errors, that thermal error represents the most significant proportion of the total volumetric error of the machine tool. Thermal error in machine tools originates from changes
Longstaff, Andrew P., Mian, Naeem, Mian, Naeem S., Fletcher, Simon, Longstaff, Andrew, Myers, Alan   +5 more
core  

The Role of Measurement and Modelling of Machine Tools in Improving Product Quality

, 2013
Manufacturing of high-quality components and assemblies is clearly recognised by industrialised nations as an important means of wealth generation. A “right first time” paradigm to producing finished components is the desirable goal to maximise economic ...
Parkinson, Simon, Fletcher S., Parkinson, S., Fletcher, Simon, S. Fletcher, Fletcher, S., Myers, Alan, Longstaff, Andrew P., Myers, A., Myers A., Longstaff, A. P., S. Parkinson, Parkinson S., Longstaff A.P., A.P. Longstaff, A. Myers   +15 more
core   +1 more source

Layered Thin Film Micro Parts Reinforced with Aligned Short Fibers in Laser Stereolithography by Applying Magnetic Field

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
The purpose of this research is to produce micro parts reinforced by unidirectional short fibers using laser stereolithography. Ferromagnetic short fibers are added to a liquid photopolymer and a magnetic field is then applied to the liquid photopolymer,
Takeshi NAKAMOTO, Shinya KOJIMA
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Mechanical characterisation and modelling of resistance welding [PDF]

, 2010
Resistance welding is used very extensively in industry for a wide range of applications. Knowledge and measurement of the dynamic characteristics of resistance welding equipment is important in the design of the equipment and in optimization of ...
Van Rymenant, Patrick
core  

Whisker Alignment in Microparts Using Laser Stereolithography with Applied Electric Field

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
The purpose of this research is to produce microparts reinforced with unidirectional whiskers using laser stereolithography. Electrically conductive whiskers are added to a liquid photopolymer and an electric field is applied to the liquid photopolymer ...
Takeshi NAKAMOTO, Osamu KANEHISA, Yohei SUGAWA   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source