Results 61 to 70 of about 189,037 (316)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Effects of Physiological Loading from Patient-Derived Activities of Daily Living on the Wear of Metal-on-Polymer Total Hip Replacements

Bioengineering
The current pre-clinical testing standards for total hip replacements (THRs), ISO standards, use simplified loading waveforms that do not fully replicate real-world biomechanics. These standards provide a benchmark of data that may not accurately predict
Benjamin A. Clegg, Samuel Perry, Enrico De Pieri, Anthony C. Redmond, Stephen J. Ferguson, David E. Lunn, Richard M. Hall, Michael G. Bryant, Nazanin Emami, Andrew R. Beadling   +9 more
doaj   +1 more source

Development of a solid bolt/nut model utilized in 3D-FE structural analysis for bolted joints

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
This study aims to develop a solid bolt/nut model utilized in 3D-FE analysis for the strength design of mechanical structures with bolted joints to obtain the internal forces and the bending moment acting on the bolt/nut assembly.
Masaya HAGIWARA, Tomohiro KAWAMURA
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

HIGH SPEED FUNCTIONALITY OPTIMIZATION OF FIVE-PHASE PM MACHINE USING 3RD HARMONIC CURRENT [PDF]

, 2013
This project was supported by the Laboratory of Electrical Engineering and Power Electronics (L2EP) France. It is a successive cooperation project between the control team and optimization team of the laboratory .Some surrogate-assisted optimization ...
GONG, Jinlin, ASLAN, Bassel, SEMAIL, Eric, GONG, Jilin, GILLON, Frédéric   +4 more
core  

Theoretical Analysis and Optimum Design of High Speed Gas Film Thrust Bearings

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2007
This paper describes the theoretical and experimental investigations of static and dynamic characteristics of four types of high-speed gas film thrust bearings, such as stepped, pocketed, spiral and herring bone grooved bearings.
Hiromu HASHIMOTO, Masayuki OCHIAI
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study of the Control Mechanism of a Half-Toroidal CVT during Load Transmission

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2007
In November 1999, the first vehicle with a traction drive CVT (continuously variable transmission) was manufactured and introduced to the market. The speed ratio changing mechanism of the half-toroidal CVT was theoretically analyzed by applying two ...
Shinji MIYATA, Darping LIU
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Uninterrupted Transmission System for Realizing High Flexibility in Design of Angular Velocity Ratio

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
Geared transmissions are used in a variety of mechanical devices to realize a wide range of speeds or torques. However, the transmission of power and motion in a geared transmission is interrupted when the working gear pairs are changed to vary the ...
Jungchul KANG, Masaharu KOMORI
doaj   +1 more source