Results 31 to 40 of about 1,043,746 (297)

Multinational License Plate Recognition Using Generalized Character Sequence Detection

IEEE Access, 2020
Automatic license plate recognition (ALPR) is generally considered a solved problem in the computer vision community. However, most of the current works on ALPR are designed to work on license plates (LP) from specific countries and use country-specific ...
Chris Henry, Sung Yoon Ahn, Sang-Woong Lee   +2 more
doaj   +1 more source

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül, Neriman Sıla Koç, Berrak Itır Aylı   +2 more
wiley   +1 more source

In Vivo Quantification of the Effectiveness of Topical Low-Dose Photodynamic Therapy in Wound Healing Using Two-Photon Microscopy

Pharmaceutics, 2022
The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm2).
Hala Zuhayri, Viktor V. Nikolaev, Anastasia I. Knyazkova, Tatiana B. Lepekhina, Natalya A. Krivova, Valery V. Tuchin, Yury V. Kistenev   +6 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Equivariant diffusion for structure-based de novo ligand generation with latent-conditioning

Journal of Cheminformatics
We introduce PoLiGenX, a novel generative model for de novo ligand design that employs latent-conditioned, target-aware equivariant diffusion. Our approach leverages the conditioning of the ligand generation process on reference molecules located within ...
Tuan Le, Julian Cremer, Djork-Arné Clevert, Kristof T. Schütt   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Identifying gene-specific subgroups: an alternative to biclustering

BMC Bioinformatics, 2019
Background Transcriptome analysis aims at gaining insight into cellular processes through discovering gene expression patterns across various experimental conditions.
Vincent Branders, Pierre Schaus, Pierre Dupont   +2 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Quantum-Enhanced Machine Learning [PDF]

Physical Review Letters, 2016
5+15 pages. This paper builds upon and mostly supersedes arXiv:1507.08482. In addition to results provided in this previous work, here we achieve learning improvements in more general environments, and provide connections to other work in quantum machine learning. Explicit constructions of oracularized environments given in arXiv:1507.08482 are omitted
Dunjko, Vedran, Taylor, Jacob M., Briegel, Hans J.   +2 more
openaire   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source