Results 161 to 170 of about 2,976,436 (174)

Transcriptomic profiling during normothermic machine perfusion of human kidneys reveals a pro-inflammatory cellular landscape and gene expression signature associated with prolonged delayed graft function after transplantation

Spiers H, Hosgood S, Larraz M, Stadler L, Zhai Y, Moon H, MacMillan S, Paterson A, Nicholson M, Mohorianu I, Kosmoliaptsis V.   +10 more
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Acute rejection after liver transplantation with machine perfusion versus static cold storage: A systematic review and meta-analysis

Hepatology, 2023
Background and Aims: Acute cellular rejection (ACR) is a frequent complication after liver transplantation. By reducing ischemia and graft damage, dynamic preservation techniques may diminish ACR.
M. Maspero, K. Ali, B. Cazzaniga, S. Yilmaz, Roma Raj, Qiang Liu, C. Quintini, C. Miller, K. Hashimoto, R. Fairchild, A. Schlegel   +10 more
semanticscholar   +1 more source

Normothermic Machine Perfusion Systems: Where Do We Go From Here?

Transplantation, 2023
Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating physiological conditions such as body temperature. Recent advancements in NMP system design have prompted the development of clinically effective devices for liver, heart,
S. López-Martínez, C. Simón, X. Santamaria   +2 more
semanticscholar   +1 more source

Normothermic Machine Perfusion for Declined Livers: A Strategy to Rescue Marginal Livers for Transplantation.

Journal of the American College of Surgeons, 2023
BACKGROUND Organ waste is a major cause of the donor liver shortage. Roughly 67% of recovered organ donors have liver utilization annually. A new technology called Normothermic Machine Perfusion (NMP) offers a way to recover marginal and declined livers ...
Franklin C. Olumba, F. Zhou, Yikyung Park, W. Chapman   +3 more
semanticscholar   +1 more source

Obstacles to implement machine perfusion technology in routine clinical practice of transplantation - Why are we not there yet ?

Hepatology, 2023
Machine perfusion of solid human organs is an old technique, and the basic principles were presented as early as in 1855 by Claude Barnard. More than 50years ago, the first perfusion system was used in clinical kidney transplantation.
Mauricio Flores Carvalho, Y. Boteon, J. Guarrera, P. Modi, L. Lladó, G. Lurje, M. Kasahara, P. Dutkowski, A. Schlegel   +8 more
semanticscholar   +1 more source

Machine perfusion in liver transplantation

Hepatology, 2022
Although liver transplantation is a true success story, many patients still die awaiting an organ. The increasing need for liver grafts therefore remains an unsolved challenge to the transplant community.
R. X. Sousa Da Silva, Achim Weber, P. Dutkowski, P. Clavien   +3 more
semanticscholar   +1 more source

Ex vivo kidney machine perfusion: meta-analysis of randomized clinical trials.

British Journal of Surgery
BACKGROUND Machine perfusion is an organ preservation strategy used to improve function over simple storage in a cold environment. This article presents an updated systematic review and meta-analysis of machine perfusion in deceased donor kidneys ...
Minseok Kang, Seonju Kim, Ji Yoon Choi, Kyeong Sik Kim, Yun Kyung Jung, Boyoung Park, Dongho Choi   +6 more
semanticscholar   +1 more source

Hypothermic Oxygenated Machine Perfusion Reduces Early Allograft Injury and Improves Post-transplant Outcomes in Extended Criteria Donation Liver Transplantation From Donation After Brain Death

Annals of Surgery, 2021
Supplemental Digital Content is available in the text Objective: The aim of this study was to evaluate peak serum alanine aminotransferase (ALT) and postoperative clinical outcomes after hypothermic oxygenated machine perfusion (HOPE) versus static cold ...
Z. Czigany, J. Pratschke, J. Fronek, M. Guba, W. Schöning, D. Raptis, J. Andrassy, M. Kramer, P. Strnad, R. Tolba, Wenjia Liu, T. Keller, Hannah Miller, Sandra Pavicevic, Deniz Uluk, M. Kocik, Isabella Lurje, C. Trautwein, A. Mehrabi, I. Popescu, F. Vondran, C. Ju, F. Tacke, U. Neumann, G. Lurje   +24 more
semanticscholar   +1 more source

The Current Landscape of Liver Transplantation After Ex Situ Machine Perfusion and Normothermic Regional Perfusion in the United States

Liver transplantation, 2022
In the United States, there remains a discrepancy between the number of liver transplantation (LT) candidates awaiting transplantation and the availability of donor organs.
K. Croome, Shennen A. Mao, C. Taner
semanticscholar   +1 more source

Cerium oxide nanoparticles administration during machine perfusion of discarded human livers: A pilot study

Liver transplantation, 2022
The combined approach of ex situ normothermic machine perfusion (NMP) and nanotechnology represents a strategy to mitigate ischemia/reperfusion injury in liver transplantation (LT).
S. Del Turco, V. Cappello, C. Tapeinos, Aldo Moscardini, L. Sabatino, M. Battaglini, F. Melandro, F. Torri, Caterina Martinelli, S. Babboni, Beatrice Silvestrini, R. Morganti, M. Gemmi, P. De Simone, Paulo N. Martins, L. Crocetti, A. Peris, D. Campani, G. Basta, G. Ciofani, D. Ghinolfi   +20 more
semanticscholar   +1 more source