Results 61 to 70 of about 2,924,807 (328)

AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion

Nature Biotechnology
Therapeutic efficacy and safety of adeno-associated virus (AAV) liver gene therapy depend on capsid choice. To predict AAV capsid performance under near-clinical conditions, we established side-by-side comparison at single-cell resolution in human livers
Jae-Jun Kim, Simone N. T. Kurial, P. Choksi, Miguel Nunez, Tyler Lunow-Luke, Jan Bartel, Julia Driscoll, C. Her, Simaron Dhillon, William Yue, Abhishek Murti, Tin Mao, Julian N Ramos, Amita Tiyaboonchai, Markus Grompe, Aras N. Mattis, Shareef M. Syed, Bruce M Wang, J. Maher, Garrett R. Roll, Holger Willenbring   +20 more
semanticscholar   +1 more source

Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: A European observational cohort study

American Journal of Transplantation, 2022
A short period (1–2 h) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia‐reperfusion injury‐related complications after liver transplantation.
I. Brüggenwirth, Matteo Mueller, V. Lantinga, S. Camagni, R. De Carlis, L. D. De Carlis, M. Colledan, D. Dondossola, M. Drefs, J. Eden, D. Ghinolfi, D. Koliogiannis, G. Lurje, T. Manzia, D. Monbaliu, P. Muiesan, D. Patrono, J. Pratschke, R. Romagnoli, M. Rayar, F. Roma, A. Schlegel, P. Dutkowski, R. Porte, V. D. de Meijer   +24 more
semanticscholar   +1 more source

The dawn of liver perfusion machines [PDF]

Current Opinion in Organ Transplantation, 2018
Despite high demand, a severe shortage of suitable allografts limits the use of liver transplantation for the treatment of end-stage liver disease. The transplant community is turning to the utilization of high-risk grafts to fill the void. This review summarizes the reemergence of ex-vivo machine perfusion for liver graft preservation, including ...
Danielle, Detelich, James F, Markmann
openaire   +2 more sources

24-hour Perfusion of Porcine Myocutaneous Flaps Mitigates Reperfusion Injury: A 7-day Follow-up Study

Plastic and Reconstructive Surgery, Global Open, 2022
Background:. Static cold storage is the gold standard of preservation in vascularized composite allotransplantation and allows a preservation time of 4–6 hours. Machine preservation is a promising technique for prolonged preservation; however, studies on
Kaj Brouwers, MD, Max F. Thijssen, MD, Anne Sophie Kruit, PhD, Dominique van Midden, MD, Erik J. Koers, BsC, Her J.H. Zegers, Ing., Stefan Hummelink, PhD, Dietmar J.O. Ulrich, MD, PhD   +7 more
doaj   +1 more source

Contrast-enhanced ultrasound examination for the assessment of renal perfusion in cats with chronic kidney disease [PDF]

, 2017
Background: Contrast-enhanced ultrasound examination (CEUS) is a functional imaging technique allowing noninvasive assessment of tissue perfusion. Studies in humans show that the technique holds great potential to be used in the diagnosis of chronic ...
Daminet, Sylvie, Duchateau, Luc, Paepe, Dominique, Saunders, Jimmy, Stock, Emmelie, Vandermeulen, Eva, Vanderperren, Katrien   +6 more
core   +2 more sources

Experimental Evaluation of a New Perfusion Machine Using Normothermic Cycles on Explanted Livers

IEEE Open Journal of Engineering in Medicine and Biology
Goal: Organ perfusion is a vast subject with several techniques, the most common being Hypothermic Machine Perfusion (HMP) and Normothermic Machine Perfusion (NMP).
Eleonora Barcali, Lorenzo Maggi, Rebecca Panconesi, Fabio Staderini, Leonardo Bocchi, Cosimo Nardi, Nadia Navari, Adriano Peris, Matteo Risaliti, Mauricio F. Carvalho, Fabio Marra, Philipp Dutkowski, Gian Luca Grazi, Andrea Schlegel, Filippo Bigi, Mattia Dimitri, Andrea Corvi   +16 more
doaj   +1 more source

Stepped vitrification technique for human ovarian tissue cryopreservation [PDF]

, 2019
The advantage of stepped vitrification (SV) is avoiding ice crystal nucleation, while decreasing the toxic effects of high cryoprotectant concentrations. We aimed to test this method for human ovarian tissue cryopreservation.
Amorin, C.A., Camboni, A., Corral, A., Dolmans, M.M., Kilbride, P., Leonel, E.C.R., Morris, John G., Risco, Ramón, Taboga, S.R., Vázquez, Marina   +9 more
core   +1 more source

Cerebral Pulsed Arterial Spin Labeling Perfusion Weighted Imaging Predicts Language and Motor Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy

Frontiers in Pediatrics, 2020
Rationale and Objectives: To compare cerebral pulsed arterial spin labeling (PASL) perfusion among controls, hypoxic ischemic encephalopathy (HIE) neonates with normal conventional MRI(HIE/MRI⊕), and HIE neonates with abnormal conventional MRI(HIE/MRI⊖).
Qiang Zheng, Juan Sebastian Martin-Saavedra, Sandra Saade-Lemus, Arastoo Vossough, Arastoo Vossough, Giulio Zuccoli, Fabrício Guimarães Gonçalves, Colbey W. Freeman, Minhui Ouyang, Varun Singh, Michael A. Padula, Michael A. Padula, Sara B. Demauro, Sara B. Demauro, John Flibotte, John Flibotte, Eric C. Eichenwald, Eric C. Eichenwald, John A. Detre, Raymond Wang Sze, Raymond Wang Sze, Hao Huang, Hao Huang, Misun Hwang, Misun Hwang   +24 more
doaj   +1 more source

Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses

Frontiers in Immunology, 2022
Access to liver transplantation is limited by a significant organ shortage. The recent introduction of machine perfusion technology allows surgeons to monitor and assess ex situ liver function prior to transplantation. However, many donated organs are of
Siavash Raigani, Siavash Raigani, John Santiago, Anders Ohman, Megan Heaney, Sofia Baptista, Sofia Baptista, Taylor M. Coe, Reinier J. de Vries, Ivy Rosales, Angela Shih, James F. Markmann, James F. Markmann, Philip Gruppuso, Korkut Uygun, Korkut Uygun, Jennifer Sanders, Heidi Yeh   +17 more
doaj   +1 more source

Normothermic Ex Vivo Machine Perfusion of Discarded Human Pancreas Allografts: A Feasibility Study

Transplant International, 2023
Pancreas transplantation is the only curative treatment for patients with complicated diabetes, and organ shortage is a common and increasing problem. Strategies to expand the donor pool are needed, and normothermic ex vivo perfusion of the pancreas has ...
C. Parmentier, S. Ray, L. Mazilescu, Masataka Kawamura, Yuki Noguchi, E. Nogueira, Sujani Ganesh, Bhranavi Arulratnam, S. Kalimuthu, M. Selzner, T. Reichman   +10 more
semanticscholar   +1 more source