Results 61 to 70 of about 335 (211)

Reference Knowledgeable Network for Machine Reading Comprehension

IEEE/ACM Transactions on Audio, Speech, and Language Processing, 2022
Multi-choice Machine Reading Comprehension (MRC) as a challenge requires models to select the most appropriate answer from a set of candidates with a given passage and question. Most of the existing researches focus on the modeling of specific tasks or complex networks, without explicitly referring to relevant and credible external knowledge sources ...
Yilin Zhao, Zhuosheng Zhang 0001, Hai Zhao 0001   +2 more
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Biomedical relation extraction via knowledge-enhanced reading comprehension

BMC Bioinformatics, 2022
Background In biomedical research, chemical and disease relation extraction from unstructured biomedical literature is an essential task. Effective context understanding and knowledge integration are two main research problems in this task.
Jing Chen, Baotian Hu, Weihua Peng, Qingcai Chen, Buzhou Tang   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Multigranularity Syntax Guidance with Graph Structure for Machine Reading Comprehension

Applied Sciences, 2022
In recent years, pre-trained language models, represented by the bidirectional encoder representations from transformers (BERT) model, have achieved remarkable success in machine reading comprehension (MRC).
Chuanyun Xu, Zixu Liu, Gang Li, Changpeng Zhu, Yang Zhang   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

S2‐Net: Machine reading comprehension with SRU‐based self‐matching networks

ETRI Journal, 2019
Machine reading comprehension is the task of understanding a given context and finding the correct response in that context. A simple recurrent unit (SRU) is a model that solves the vanishing gradient problem in a recurrent neural network (RNN) using a ...
Cheoneum Park, Changki Lee, Lynn Hong, Yigyu Hwang, Taejoon Yoo, Jaeyong Jang, Yunki Hong, Kyung‐Hoon Bae, Hyun‐Ki Kim   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source