Results 81 to 90 of about 8,093 (292)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

DRCD: a Chinese Machine Reading Comprehension Dataset

open access: yesCoRR, 2018
5 ...
Chih-Chieh Shao   +4 more
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Machine Reading Comprehension Based On Multi-headed attention Model

open access: yesMATEC Web of Conferences, 2018
Machine Reading Comprehension (MRC) refers to the task that aims to read the context through the machine and answer the question about the original text, which needs to be modeled in the interaction between the context and the question.
Xu Hui, Zhang Shichang, Jiang Jie
doaj   +1 more source

Read-All-in-Once (RAiO): Multi-Layer Contextual Architecture for Long-Text Machine Reading Comprehension

open access: yesIEEE Access, 2023
Machine reading comprehension (MRC) is a cutting-edge technology in natural language processing (NLP), which focuses on teaching machines to read and understand the meaning of texts based on the emergence of large-scale datasets and neural network models.
Tuan-Anh Phan   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

TT-Net: Topic Transfer-Based Neural Network for Conversational Reading Comprehension

open access: yesIEEE Access, 2019
Conversational machine reading comprehension (MRC) is a new question answering task, which is more challenging compared to traditional single-turn MRC since it requires a better understanding of conversation history. In this paper, a novel neural network
Gu Yingjie, Gui Xiaolin, Li Defu
doaj   +1 more source

Machine Reading Comprehension Framework Based on Self-Training for Domain Adaptation

open access: yesIEEE Access, 2021
Machine reading comprehension (MRC) is a type of question answering mechanism in which a computer reads documents and answers related questions. The accuracies of recent MRC systems surpass those of humans.
Hyeon-Gu Lee, Youngjin Jang, Harksoo Kim
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Structure and access : the role of structural factors in text comprehension and information [PDF]

open access: yes, 1985
In this thesis it is argued that structural factors play an important role in facilitating the access, comprehension, and recall of textual information, especially when the content of the material is unfamiliar to the reader.
O'Malley, C.E, O'Malley, Claire E.
core  

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