Results 41 to 50 of about 5,164,018 (286)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

In-Process Monitoring of Inhomogeneous Material Characteristics Based on Machine Learning for Future Application in Additive Manufacturing

Journal of Machine Engineering
Additively manufactured components often show insufficient component quality due to the formation of different defects. Defects such as porosity result in material inhomogeneity and structural integrity issues. The integration of in-process monitoring in
André Jaquemod, Marijana Palalić, Kamil Güzel, Hans-Christian Möhring   +3 more
doaj   +1 more source

Acoustic Roughness Measurement of Railway Tracks: Running Surface Detection and Compensation of Lateral Movements for Optical Measurements on a Train

Sensors, 2023
Rolling noise is a significant contributor to railway noise. Wheel and rail roughness are decisive for the emitted noise level. An optical measurement method installed on a moving train is suitable for closer monitoring of the rail surface condition.
Florian Mauz, Remo Wigger, Loris Griesbaum, Tobias Wahl, Michal Kuffa, Konrad Wegener   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Characterization of Tool Clamping Conditions in Forging Hammers

Journal of Machine Engineering, 2022
The present work addresses the topic of die clamping at the forging hammer in the context of the definition of a current requirement profile as well as the evaluation of individual influencing variables on the clamping process.
Nico Wagner, Robert Tehel, Robin Kurth, Steffen Ihlenfeldt   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Light machine tools for productive machining

, 2011
This chapter presents an integrated 'machine and process' approach that is based onstability lobe diagrams for designing large-volume milling machines, bearing in mindtheir productivity, reliability and accuracy as well as their eco-efficiency.
Lacalle, L. N.Lopez, Campa, F. J., Zulaika, J.   +2 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source