Results 61 to 70 of about 1,714,603 (291)

Identifying the machine translation error types with the greatest impact on post-editing effort [PDF]

, 2017
Translation Environment Tools make translators' work easier by providing them with term lists, translation memories and machine translation output. Ideally, such tools automatically predict whether it is more effortful to post-edit than to translate from
Daems, Joke, Hartsuiker, Robert, Macken, Lieve, Vandepitte, Sonia   +3 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Secure data storage and service automation for cyber physical production systems through distributed ledger technologies

Journal of Machine Engineering, 2021
In this paper, we use the blockchain technology to design a prototype to secure process data from a 3D-printer. Datastreams are gathered from various sources such as OPC UA servers and autonomous retrofit sensor nodes.
Gordon Lemme, Kilian Armin Nölscher, Erhao Bei, Christian Hermeling, Steffen Ihlenfeldt   +4 more
doaj   +1 more source

Machine tools safety [PDF]

, 2012
V této bakalářské práci je vypracován přehled legislativních požadavků a směrnic požadovaných dle Evropského parlamentu a Rady v oblasti obráběcích strojů. Dále se práce zabývá harmonizovanými normami v této oblasti.
Holczer, Aleš
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Investigation of Tool Cooling and Heat Transfer Using Computational Fluid Dynamics Simulations

Journal of Machine Engineering
Thermal errors remain one of the biggest challenges for the precision of cutting machine tools. Aside from optimizations in the machine tool design and behaviour, optimal cutting process parameters and targeted usage of cutting fluid or alternative ...
Christian Naumann, Claus-Dieter Schmidt, Alexander Geist, Steffen Brier, Janine Glanzel, Philipp Klimant, Steffen Ihlenfeldt, Martin Dix   +7 more
doaj   +1 more source

Green Machine Tools [PDF]

, 2011
Tato práce se zabývá energetickou analýzou a hledáním možností úspory energie u současných obráběcích strojů. Je v ní zmíněno základní rozdělení obráběcích strojů, popisuje a analyzuje jednotlivé metody energy harvesting systémů, a hledá způsoby, jak ...
Harapát, Jan
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Milling tools for CNC machine tools [PDF]

, 2009
V této bakalářské práci jsou popsány frézovací nástroje pro CNC obráběcí stroje. První kapitola je zaměřena na CNC frézky a CNC obráběcí centra. Hlav-ní pohled je upírán na zásobníky a typy nástrojů pro CNC stroje.
Vampola, Lukáš
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source