Results 81 to 90 of about 8,584,927 (344)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Parallel kinematics for machine tools

, 2009
Parallel kinematics is a branch of mechanics that focusses on manipulators formed by closed kinematic chains, i.e., mechanisms that have an endeffector joined to the fixed frame by several limbs.
Hernández, Alfonso, Altuzarra, Oscar, Larrañaga, Josu, San Martín, Yon   +3 more
core   +1 more source

Energy efficient manufacturing from machine tools to manufacturing systems [PDF]

, 2013
46th CIRP Conference on Manufacturing Systems, 29-31st May 2013, Sesimbra, PortugalEnergy efficiency is one of the key drivers for sustainability. Within manufacturing environments, energy efficiency importance has grown, and it is now considered among ...
Salonitis, Konstantinos, Ball, Peter, Ball, Peter D.   +2 more
core   +1 more source

Machine vision in manufacturing SMEs: a review

Discover Applied Sciences
Automating manufacturing tasks, such as quality control, fault detection, part classification, and inventory management with machine vision systems can significantly improve process efficiency, accuracy, and productivity.
Jonas Werheid, Hannes Behnen, Jan-Henrik Woltersmann, Shengjie He, Tobias Hamann, Anas Abdelrazeq, Robert H. Schmitt   +6 more
doaj   +1 more source

Concept of Integrating a Hybrid Thermal Error Compensation Into an Existing Machine Tool Control Architecture

Journal of Machine Engineering
Thermal error compensation via a numeric control (NC) system is a proven option for upgrading the precision of machine tools. The main advantage is the generally cost-effective application, as no changes to the machine design are necessary. Since modern
Alexander Geist, Muhammad Faisal Yaqoob, Christian Friedrich, Christian Naumann, Steffen Ihlenfeldt   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Review of Artificial Intelligence Algorithms Used for Smart Machine Tools

Inventions, 2018
This paper offers a review of the artificial intelligence (AI) algorithms and applications presently being used for smart machine tools. These AI methods can be classified as learning algorithms (deep, meta-, unsupervised, supervised, and reinforcement ...
Chih‐Wen Chang, H. Lee, Chein-Hung Liu
semanticscholar   +1 more source

Investigation of the material separation behaviour of rocks using scratch tests for the design of tool grinding processes

SN Applied Sciences, 2022
Article Highlights Investigating material removal mechanisms of rocks against the background of tool grinding. Identifying optima of cutting speed and single grain chip thickness for ductile material removal for rocks.
Berend Denkena, Bernd Breidenstein, Benjamin Bergmann, Philipp Wolters   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Thermal error modelling of machine tools based on ANFIS with fuzzy c-means clustering using a thermal imaging camera

, 2015
Thermal errors are often quoted as being the largest contributor to CNC machine tool errors, but they can be effectively reduced using error compensation.
Longstaff, Andrew P., Fletcher, Simon, Abdulshahed, Ali, Myers, Alan, Abdulshahed, Ali M.   +4 more
core   +1 more source