Results 101 to 110 of about 8,584,927 (344)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Light machine tools for productive machining
, 2011 This chapter presents an integrated 'machine and process' approach that is based onstability lobe diagrams for designing large-volume milling machines, bearing in mindtheir productivity, reliability and accuracy as well as their eco-efficiency.
Lacalle, L. N.Lopez +2 more
core
Tool-life and wear mechanisms of CBN tools in machining of Inconel 718 [PDF]
, 2007 The demand for increasing productivity when machining heat resistant alloys has resulted in the use of new tool materials such as cubic boron nitride (CBN) or ceramics.
DESSOLY, Michel +4 more
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A Review on Real-Time Simulation of CNC Machine Tool Dynamics
, 2013 This paper is an endeavour to critically appraise the existing methods used for real-time simulation of machine tool dynamics with the emphasis on modelling and simulation of the dynamic behaviour of CNC machine tool feed drives and mechatronic systems ...
Pislaru, Crinela
core
Advanced Material Studies for Additive Manufacturing in terms of Future Gear Application
Advances in Mechanical Engineering, 2014 Additive manufacturing by laser beam melting is predestined for complex component geometry like integrated cooling channels without enormous posttreatment processing.
Jan Bräunig +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Comparison of Volumetric Analysis Methods for Machine Tools with Rotary Axes
, 2009 Confidence in the ability of a production machine to meet manufacturing tolerances requires a full understanding of the accuracy of the machine. However, the definition of “the accuracy of the machine” is open to interpretation. Historically, this has
Longstaff, Andrew P. +3 more
core
The application of ANFIS prediction models for thermal error compensation on CNC machine tools
, 2015 Thermal errors can have significant effects on CNC machine tool accuracy. The errors come from thermal deformations of the machine elements caused by heat sources within the machine structure or from ambient temperature change.
Longstaff, Andrew P. +3 more
core +1 more source