Results 91 to 100 of about 8,584,927 (344)

Modelling of a Thermoelectric Self-Cooling System Based on Thermal Resistance Networks for Linear Direct Drives in Machine Tools

Journal of Machine Engineering, 2020
The use of direct drives in linear and rotary axes as well as increased power density of main drives offer the potential to raise feet rate, acceleration and thus allow higher productivity of machine tools.
Eckart UHLMANN, Sebastian SALEIN, Mitchel POLTE, Florian TRIEBEL   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Predictive Technology Assessment by Means of a Structure-Based Method of Machine Learning

Journal of Machine Engineering, 2020
From a user perspective, the current development of the generic term Industry 4.0 increasingly moves its orientation towards flexible production. Due to increasingly variable products with small quantities and the resulting high degree of adaptability of
Manja Mai-Ly PFAFF, Uwe FRIEß, Andreas OTTO, Matthias PUTZ   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Performance evaluation of a new taut wire system for straightness measurement of machine tools

, 2014
This paper describes evaluation of a method of measuring the straightness of motion of machine tool axes using a taut wire and an optical sensor head mounted at the tool point location. In contrast to commonly used taut wire instruments, straightedges or
Longstaff, Andrew P., Fletcher, Simon, Borisov, Oleg, Longstaff, Andrew, Myers, Alan   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Thermal Analysis for Condition Monitoring of Machine Tool Spindles

, 2012
Decreasing tolerances on parts manufactured, or inspected, on machine tools increases the requirement to have a greater understanding of machine tool capabilities, error sources and factors affecting asset availability. Continuous usage of a machine tool
Willoughby, P., Longstaff, Andrew P., Longstaff, A. P., Fletcher, Simon, Willoughby, Peter, Clough, D., Fletcher, S., Clough, David A   +7 more
core   +1 more source

Influence of the Substrate Size on the Cooling Behavior and Properties of the DED-LB Process

Journal of Machine Engineering
The laser-based Directed Energy Deposition (DED-LB) process involves a complex thermal history which strongly de-pends on the geometry of the deposited structure and substrate.
Fabian Bieg, Clemens Maucher, Hans-Christian Möhring   +2 more
doaj   +1 more source