Results 71 to 80 of about 5,164,018 (286)
Journal of Machine Engineering, 2020 The use of direct drives in linear and rotary axes as well as increased power density of main drives offer the potential to raise feet rate, acceleration and thus allow higher productivity of machine tools.
Eckart UHLMANN +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Predictive Technology Assessment by Means of a Structure-Based Method of Machine Learning
Journal of Machine Engineering, 2020 From a user perspective, the current development of the generic term Industry 4.0 increasingly moves its orientation towards flexible production. Due to increasingly variable products with small quantities and the resulting high degree of adaptability of
Manja Mai-Ly PFAFF +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cyber-physical Machine Tool – The Era of Machine Tool 4.0
Procedia CIRP, 2017 In the past five years, several industrial initiatives such as “Industry 4.0”, “Industrial Internet of Things”, “Factories of the Future” and “Made in China 2025”, have been announced by different governments and industrial leaders. These initiatives lead to an urgent need to advance current manufacturing systems into a high level of intelligence and ...
Liu, Chao, Xu, Xun
openaire +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Opening of Production Engineering Machine Tools Laboratory, 1961 -- 01
, 1961 Opening of Production Engineering Machine Tools Laboratory, by O.E.
Swinburne Technical College
core
Tilted Tool Axis Machining on 5-Axis Machine Tools
International Journal of Automation Technology, 2007 High-efficiency machining and high-quality cutting are required in mold and die machining. To produce high-quality molds and dies, we require high rigidity for cutting tools and machining with effective cutting edges. We propose tilted tool axis machining, which involves indexing using 2-axis rotary motion and machining using 3-axis feed motion on ...
Makoto Yamada +3 more
openaire +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source