Results 81 to 90 of about 2,609,056 (293)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Statistically motivated example-based machine translation using translation memory [PDF]

, 2010
In this paper we present a novel way of integrating Translation Memory into an Example-based Machine translation System (EBMT) to deal with the issue of low resources. We have used a dialogue of 380 sentences as the example-base for our system.
Morrissey, Sara, Somers, Harold, Kumar Naskar, Sudip, Dandapat, Sandipan   +3 more
core   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A SYSTEMATIC READING IN STATISTICAL TRANSLATION: FROM THE STATISTICAL MACHINE TRANSLATION TO THE NEURAL TRANSLATION MODELS.

Journal of ICT, 2017
Achieving high accuracy in automatic translation tasks has been one of the challenging goals for researchers in the area of machine translation since decades.
Zakaria El Maazouzi, Badr Eddine El Mohajir, Mohammed Al Achhab   +2 more
doaj   +3 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The machine translator’s visibility

Translation Spaces
Abstract This article proposes that machine and human translation differ in use and seeks to demonstrate this not by comparison, but rather using the framework from philosophy of technology known as postphenomenology. Following the work of Don Ihde and others, postphenomenology is intended to examine how technologies mediate
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Comparative analysis of machine translation for Hindi-Dogri text using rule-based, statistical, and neural approaches [PDF]

PeerJ Computer Science
Machine translation has made significant progress in several Indian languages; however, some, known as computationally low-resourced languages, have seen very little work in this field.
Joginder Kumar, Manik Rakhra, Preeti Dubey, Deepak Prashar, Leo Mrsic, Arfat Ahmad Khan, Seifedine Kadry, Jungeun Kim   +7 more
doaj   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source