Results 111 to 120 of about 3,545,542 (409)

Experimental study of coated carbide tools behaviour: application for Ti-5-5-5-3 turning [PDF]

, 2011
The goal of this paper is to study the relation between the input data (conditions and geometry of cut) and answers (wear of tool, forces and cutting temperatures) when machining the Ti-5-5-5-3 alloy treated. This study has shown that the cutting process
Baili, Maher, Dessein, Gilles, Lallement, Daniel, Wagner, Vincent   +3 more
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Method of determining the process applied for feature machining : experimental validation of a slot [PDF]

, 2007
In this paper, we will be evaluating the "manufacturability" levels for several machining processes of "slot" feature. Using the STEP standard, we will identify the slot feature characteristics. Then, using the ascendant generation of process method, we
D'ACUNTO, Alain, MARTIN, Patrick
core   +5 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The Migration Machine

, 2011
Anyone travelling to Europe these days comes across not only barriers but also an increasing amount of technology. Bona fide travellers are offered high-tech initiatives (such as iris scans) in the hope that the desire for safety can still be combined with freedom of movement for all citizens.
Dijstelbloem, H., Meijer, A., Besters, M.   +2 more
openaire   +5 more sources

Design of an electrochemical micromachining machine [PDF]

, 2014
Electrochemical micromachining (μECM) is a non-conventional machining process based on the phenomenon of electrolysis. μECM became an attractive area of research due to the fact that this process does not create any defective layer after machining and ...
A Muetze, A Spieser, AB Kamaraj, AB Kamaraj, AL Trimmer, Alexandre Spieser, Atanas Ivanov, AW Labib, B Bhattacharyya, BJ Park, C-T Lin, D Huo, DS Bilgi, ES Lee, G Skrabalak, HS Shin, J Kozak, J Kozak, JA McGeough, KP Rajurkar, KP Rajurkar, L Cagnon, M Datta, M Kock, M Sen, M Wang, MAH Mithu, MAH Mithu, PT Stanev, R Schuster, S Burkert, TKKR Mediliyegedara, U Çaydaş, V Kirchner, X Lu, X Luo, Y Lu, YJ Zhang, Z Zhang, Z Zhang, Z-W Fan   +40 more
core   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Parallel machines scheduling with machine shutdowns

Computers & Mathematics with Applications, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hwang, HC, Chang, SY
openaire   +4 more sources

Field Induced Jet Micro-EDM [PDF]

, 2013
Electrical discharge machining (EDM) is of the potential of micro/nano meter scale machining capability. However, electrode wear in micro-EDM significantly deteriorates the machining accuracy, thus, it needs to be compensated in process.
Kang, Xiaoming, Xu, Kaixian, Zhao, Wansheng   +2 more
core   +1 more source