Results 121 to 130 of about 3,639,668 (395)
Molecular Oncology, EarlyView.We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin +10 more
wiley +1 more source
An improved approach for automatic process plan generation of complex borings [PDF]
, 2006 The authors are grateful for funding provided to this project by the French Ministry of Industry, Dassault Aviation, Dassault Systemes, and F. Vernadat for his review and recommendations.The research concerns automated generation of process plans using ...
DANTAN, Jean-Yves +3 more
core +5 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Materials & DesignMetal matrix composites (MMCs) offer unique advantageous mechanical properties by strengthening a ductile metal matrix with a ceramic reinforcement (e.g., Ti6Al-4 V/SiCf).
Omkar Mypati +5 more
doaj +1 more source
Optimization of 5-axis milling processes using process models [PDF]
, 2006 Productivity and part quality are extremely important for all machining operations, but particularly for 5-axis milling where the machine tool cost is relatively higher, and most parts have complex geometries and high quality requirements with tight ...
Budak, Erhan +4 more
core
PLoS Genetics, 2008 Until recently, sequencing the entire genome of an organism was a major endeavor. New technologies are transforming this task into routine practice and launching a new assault on whole-genome sequencing. It is more than 30 years since Sir Fred Sanger and colleagues published their method for sequencing DNA [1].
Leonid Kruglyak, David Gresham
openaire +5 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Apparatus for machining geometric cones Patent [PDF]
, 1968 Rotary spindle lathe attachments for machining geometrical ...
Allen, J. H., Sr., Wobig, O. A.
core +1 more source
Comprehension of chip formation in laser assisted machining [PDF]
, 2011 Laser Assisted Machining (LAM) improves the machinability of materials by locally heating the workpiece just prior to cutting. Experimental investigations have confirmed that the cutting force can be decreased, by as much as 40%, for various materials ...
DAL SANTO, Philippe +2 more
core +3 more sources
A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications
Molecular Oncology, EarlyView.Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker +3 more
wiley +1 more source