Results 121 to 130 of about 3,545,542 (409)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
PLoS Genetics, 2008 Until recently, sequencing the entire genome of an organism was a major endeavor. New technologies are transforming this task into routine practice and launching a new assault on whole-genome sequencing. It is more than 30 years since Sir Fred Sanger and colleagues published their method for sequencing DNA [1].
Leonid Kruglyak, David Gresham
openaire +5 more sources
Toolpath dependent stability lobes for the milling of thin-walled parts [PDF]
, 2008 The milling of thin-walled parts can become a seriously complex problem because the parts have variable dynamics. Firstly, the dynamics evolution of the part has been calculated through Finite Element Method (FEM) analysis.
Aramendi, Gorka +5 more
core +3 more sources
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
DIFFERENTIAL EVOLUTION FOR OPTIMIZATION OF PID GAIN IN ELECTRICAL DISCHARGE MACHINING CONTROL SYSTEM [PDF]
, 2012 PID controller of servo control system maintains the gap between Electrode and workpiece in Electrical Dis- charge Machining (EDM). Capability of the controller is significant since machining process is a stochastic phenomenon and physical behaviour of ...
Andromeda, Trias +4 more
core
Surface roughness variation of thin wall milling, related to modal interactions [PDF]
, 2008 High-speed milling operations of thin walls are often limited by the so-called regenerative effect that causes poor surface finish. The aim of this paper is to examine the link between chatter instability and surface roughness evolution for thin wall ...
Assouline +21 more
core +4 more sources
Optimization experiment on eccentric lapping of cylindrical rollers
Nanotechnology and Precision Engineering, 2018 Cylindrical rollers are important elements of bearings, and their machining accuracy and consistency affect the bearing quality. Using a GCr15 cylindrical roller of Ф11 × 12 as the processing object in this study, the effects of loading pressure ...
Jia Su +3 more
doaj
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source