Results 111 to 120 of about 119,208 (317)

Key Parameters In Loose Abrasive Machining

, 2010
Loose abrasive machining is discussed in this paper. Key parameters of loose abrasive machining such as lapping and polishing are reviewed under systematic view of manufacturing system. Currently, such parameters considered as tacit knowledge. Different
Arief, Ikhwan, Chen, Xun
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Comparative features of plasma electrolytic nitrocarburizing of Ti6Al4V alloy produced by traditional, SLM, and EBM methods

Next Materials
The efficacy of plasma electrolytic nitrocarburizing (PENC) in enhancing the surface hardness and wear resistance of the surface of Ti6Al4V alloy additively manufactured by selective laser melting (SLM) and electron beam melting (EBM) was assessed in ...
S.N. Grigoriev, I.V. Tambovskiy, T.L. Mukhacheva, I.A. Kusmanova, V.A. Gaponov, I.R. Palenov, P.A. Podrabinnik, I.V. Suminov, S.A. Kusmanov   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Machining

, 2009
I examine in this paper the machining of steels by means of turning process, the chip removal and friction phenomenon during machining. I deal with energy's balance sheet of cutting of steel and I suggest a newer direction the machining technology based ...
Valasek István, Kári-Horváth Attila
core  

Characterisation of integrated WAAM and machining processes [PDF]

, 2013
This research describes the process of manufacturing and machining of wire and arc additive manufactured (WAAM) thin wall structures on integrated and non¬integrated WAAM systems.
Adebayo, Adeyinka
core  

Cryogenic Machining-Induced Surface Integrity: A Review and Comparison with Dry, MQL, and Flood-Cooled Machining

, 2014
The process of cryogenic machining, due to increased demand for environmentally friendly manufacturing processes, has seen a growing interest in the machining community.
KAYNAK, YUSUF
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Machining of aluminium based Metal Matrix Composite (MMC) [PDF]

The machining of aluminium 2618 particulate reinforced Metal Matrix Composite (MMC) with 18 vol. % silicon carbide (SiC) using cemented carbide cutting tools has been undertaken.
Abdullah, Abu
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source