Results 131 to 140 of about 3,545,542 (409)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Optimization of 5-axis milling processes using process models [PDF]

open access: yes, 2006
Productivity and part quality are extremely important for all machining operations, but particularly for 5-axis milling where the machine tool cost is relatively higher, and most parts have complex geometries and high quality requirements with tight ...
Budak, Erhan   +4 more
core  

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

Predecessor machines

open access: yesJournal of Computer and System Sciences, 1974
A predecessor machine is a random-access machine with a predecessor operation (i.e., an instruction which subtracts 1 from the contents of a memory cell), but with no operation which can increase the contents of a cell. A regressing function is a partial function which never yields an output larger than the maximum of its inputs and a constant.
John C. Warkentin, Patrick C. Fischer
openaire   +2 more sources

You Say Takings, and I Say Takings: The History and Potential of Regulatory Takings Challenges to the Endangered Species Act [PDF]

open access: yes, 2006
The precision of machining systems is ever increasing in order to keep up with components’ accuracy requirements. At the same time product variants areincreasing and order quantities are decreasing, which introduces high demands on the capability of ...
Botello-Samson, Darren
core   +1 more source

Study on propagation characteristics of laser in turbulent Rayleigh–Bénard thermal convection

open access: yesThe Journal of Engineering, 2019
The turbulent Rayleigh–Bénard (R–B) convection system contains the plume and the large-scale circulation structure, which causes the statistical inhomogeneity of the flow field.
Zhichao Zhou   +7 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Influence of Tool-Workpiece Interface on Surface Integrity after Turning

open access: yesCommunications, 2014
This paper deals with influence of flank wear on decomposition of cutting force in turning roll bearing steel. The decomposition is carried out to evaluate the components of cutting force in the tool-chip as well as tool-workpiece interface.
Jaroslav Dubec   +3 more
doaj   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

open access: yesMolecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy