Results 161 to 170 of about 119,208 (317)

The Effect of Interatomic Potentials on Nanometric Abrasive Machining

, 2010
One of the major tasks in a Molecular Dynamics (MD) simulation is the selection of adequate potential functions, and if the potentials don’t model the behaviour of the atoms correctly, the results produced from the simulation would be useless.
Oluwajobi, Akinjide O., Chen, Xun
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Fabrication of a side aligned optical fibre inteferometer by focused ion beam machining

, 2013
Focused ion beam (FIB) machining is a promising technique for the fabrication of micro-optical components with high quality surface finishes. In this work, a prototype of a side aligned optical fibre interferometer was successfully fabricated by the ...
Ritchie, J. M., Maier, R R J, Li, J, Hand, D P; id_orcid, Luo, X, Hand, D P, Sun, J, MacPherson, W. N., Luo, Xichun, Ritchie, J M, Macpherson, W N; id_orcid, Miller, M K, Maier, R R J; id_orcid, sun, jining   +13 more
core   +1 more source

Machine collaboration

Stat
We propose a new ensemble framework for supervised learning, called machine collaboration (MaC), using a collection of possibly heterogeneous base learning methods (hereafter, base machines) for prediction tasks.
Qingfeng Liu, Yang Feng
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Simulating the Heat Distortiion of a Cast Iron Brake Disc during Dry Machining [PDF]

, 2012
The application of MQL or dry machining in mass production becomes more and more accepted. Dry (MQL) machining is a very efficient solution to reduce the usage of cutting fluids and represents an effective measure for an environmental friendly production.
KOPPKA, Frank, RANC, Nicolas, BOYER, Henri-François, Koppka, F., LORONG, Philippe, FRABOLOT, M.   +5 more
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Investigation into the effect of fixturing systems on the design of condition monitoring for machining operations

, 2013
The global market competition has drawn the manufacturer’s attention on automated manufacturing processes using condition monitoring systems. These systems have been used for improving product quality, eliminating inspection, and enhancing manufacturing ...
Abbas, JK
core  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source