Results 71 to 80 of about 1,214,762 (295)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
TechnologiesOne of the limitations of additive manufacturing technology is the high surface roughness of finished products caused by the layered structure of the deposition and the effect of adhesion of unfused powder particles.
Sergey N. Grigoriev +9 more
doaj +1 more source
International Journal of Advanced Robotic Systems, 2019 Composite workpieces, especially the complex-curved surfaces composite workpieces, have been increasingly used in different industries. Non-destructive testing of these parts has become an urgent problem to be addressed.
Canzhi Guo +4 more
doaj +1 more source
Barkhausen Noise Emission in Milled Surfaces
Communications, 2015 This paper deals with the non-destructive evaluation of surface made of roll bearing steel 100Cr6 after milling cycles via Barkhausen noise technique.
Miroslav Neslusan +3 more
doaj +1 more source
Experimental study on lapping ceramic balls with variable-radius groove plate
Advances in Mechanical Engineering, 2021 The method of lapping precision ball with variable-radius groove is developed in recent years. An experimental study on lapping ceramic balls with variable-radius groove was carried out.
Fenfen Zhou +5 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
On the stability of high-speed milling with spindle speed variation [PDF]
, 2010 Spindle speed variation is a well-known technique to suppress regenerative machine tool vibrations, but it is usually considered to be effective only for low spindle speeds.
BP Mann +43 more
core +4 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Application of an Ultrashort-pulsed Laser for Generation of Super-hydrophobic Surfaces
Current Directions in Biomedical Engineering, 2021 Hydrophobic surfaces have gained a vast attention in different fields of biomedical applications over the last few years. Laser treatment has been shown as a promising technology for the generation of functional, inter alia, superhydrophobic surfaces. In
Zahedi Ali +2 more
doaj +1 more source