Results 111 to 120 of about 88,069 (311)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Investigation of tool geometry effect and penetration strategies on cutting forces during thread milling [PDF]

, 2014
The application of thread milling is increasing in industry because of its inherent advantages over other thread cutting techniques. The objective of this study is to investigate the effect of milling cutter tool geometry on cutting forces during thread ...
BRENDLEN, Romain, FROMENTIN, Guillaume, POULACHON, Gérard, SHARMA, Vishal   +3 more
core   +3 more sources

Projekt for manufacturing of gears for Company Stab spol. s r. o. [PDF]

, 2020
Diplomová práca opisuje projekt na založenie novej divízie pre firmu ktorá sa zaoberá generálnymi opravami strojov. V prvej časti práce je rozoberaná teoretická časť o výrobnom procese ozubenia a ekonomická časť tejto práce. Hlávne časti práce sú analýza
Štefan Staník
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Research on CNC machining technology of straight bevel gears based on hypocycloids

Scientific Reports
Bevel gear transmission is characterized by strong load capacity, stable transmission, and compact structure. It is a key component in power transmission systems for vehicles, ships, machine tools, oil drilling equipment, aerospace, and other industries.
Chong Tian, Taiyong Wang, Ying Tian, Xinyu Zhang   +3 more
doaj   +1 more source

A Comprehensive Evaluation Method of Machining Center Components’ Importance Based on Combined Variable Weight

Mathematics
The fault transitivity of machining center components causes their fault propagation indexes to demonstrate dynamic time variability, which affects their importance. The method proposed in this study overcomes the biases of existing methods of evaluating
Lan Luan, Guixiang Shen, Yingzhi Zhang
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Millimeter-long Fiber Fabry-Perot cavities

, 2016
We demonstrate fiber Fabry-Perot (FFP) cavities with concave mirrors that can be operated at cavity lengths as large as 1.5mm without significant deterioration of the finesse.
Garcia, Sebastien, Kohlhaas, Ralf, Long, Romain, Ott, Konstantin, Reichel, Jakob, Rosenbusch, Peter, Schüppert, Klemens   +6 more
core   +3 more sources