Results 91 to 100 of about 5,151,847 (295)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Dynamic analysis of lathe bed of woodworking CNC machining center based on the modeling of joint surface. [PDF]

PLoS One, 2022
Sun YK, Hua J, Li YN, Chen GW, Liu MH.
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Environmentally benign machining

This book provides essential information on environmentally benign/sustainable machining processes including innovations and developments in conventional machining, considering economy, safety, and productivity.
Bayraktar, Şenol, Pathak, Sunil
core   +1 more source

Reconstruction of Misalignment Aberrations for Cylindrical Surfaces with Complex Parameters in Pseudo Lateral Shearing Interferometry

Sensors
Cylindrical surfaces with complex parameters (CSCPs) have off-axis and aspheric properties. High-precision measurement of cylindrical surfaces is a key research focus in optical metrology.
Yuxuan Ren, Weizhou Luo, Yang Chen, Le Zhao, Liuqing He, Siqi Zhang, Kuo Hai, Xiaodong Zhang, Zhongming Zang   +8 more
doaj   +1 more source

Chatter Monitoring of Machining Center Using Head Stock Structural Vibration Analyzed with a 1D Convolutional Neural Network. [PDF]

Sensors (Basel), 2022
Jeong K, Seong Y, Jeon J, Moon S, Park J.   +4 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Research on CNC machining technology of straight bevel gears based on hypocycloids

Scientific Reports
Bevel gear transmission is characterized by strong load capacity, stable transmission, and compact structure. It is a key component in power transmission systems for vehicles, ships, machine tools, oil drilling equipment, aerospace, and other industries.
Chong Tian, Taiyong Wang, Ying Tian, Xinyu Zhang   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source