Results 31 to 40 of about 12,778 (269)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

TRANSIENT RESPONSE ANALYSIS OF MACHINING CENTER UNDER IMPACT OF HIGH ACCELERATION

Jixie qiangdu, 2018
The manufacturing processing of blade,which has complicated structure and irregular surface shape,become increasingly high-speed.Thus,high acceleration is required to ensure the rapid movement of each axis.At the same time,the machining accuracy should ...
MI Jie, ZHEN Zhen, ZHU YingPing
doaj  

High precision manufacturing method of multi-thread worm wheel using 5-axis machining center

Nihon Kikai Gakkai ronbunshu, 2019
In recent years, the speeding up of a rotary table using a worm gear pair has been required. In order to perform the speeding up of a rotary table, the multi-thread worm wheel is adopted in some cases. When a hob tool for cutting a worm wheel is likewise
Shigenori HAMADA, Kazumasa KAWASAKI, Isamu TSUJI   +2 more
doaj   +1 more source

Research on Abrasive Water Jet Polishing of Silicon Carbide Based on Fluid Self-Excited Oscillation Pulse Characteristics

Micromachines, 2023
A self-excited oscillating pulsed abrasive water jet polishing method is proposed to solve the problems of low removal efficiency in traditional abrasive water jet polishing and the influence of an external flow field on the material surface removal rate.
Hong Zhang, Baochun Tao, Qianfa Deng, Chengqi Zhang, Binghai Lyu, Duc-Nam Nguyen   +5 more
doaj   +1 more source

Precision Machining with Micro-Scale Vertical Machining Center

Journal of Advanced Computational Intelligence and Intelligent Informatics, 2006
Micro machining is an emerging technology with extremely large benefits and equally great challenges. The push to develop processes and tools capable of micro scale fabrication results from the widespread drive to reduce part and feature size in many industrial and commercial sectors.
Cox, Daniel J., Newby, Glynn, Park, Hyung Wook, Steven, Y. Liang, Liu, Wang-Lin, Hsieh, Shang-Bin, Hwang, Joon   +6 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source