Results 51 to 60 of about 88,069 (311)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Modeling of Flexible Bodies for the Study of Control in the Simulink Environment

Applied Sciences, 2020
When studying complex mechatronic systems, it is useful to build models able to simulate both the dynamics of the phenomenon and the control system applied. Typically, the bodies involved are modeled as rigid bodies.
Laura Salamina, Daniele Botto, Stefano Mauro, Stefano Pastorelli   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Study on Kinematic Structure Performance and Machining Characteristics of 3-Axis Machining Center

Applied Sciences, 2023
The rigidity and natural frequency of machine tools considerably influence cutting and generate great forces when the tool is in contact with the workpiece.
Tzu-Chi Chan, Chia-Chuan Chang, Aman Ullah, Han-Huei Lin   +3 more
doaj   +1 more source

Latest Developments in Industrial Hybrid Machine Tools that Combine Additive and Subtractive Operations [PDF]

, 2018
Hybrid machine tools combining additive and subtractive processes have arisen as a solution to increasing manufacture requirements, boosting the potentials of both technologies, while compensating and minimizing their limitations.
Arrizubieta Arrate, Jon Iñaki, Cortina Burón, Magdalena, Lamikiz Mentxaka, Aitzol, Ruiz Salas, José Exequiel, Ukar Arrien, Eneko   +4 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Precision Machining with Micro-Scale Vertical Machining Center

Journal of Advanced Computational Intelligence and Intelligent Informatics, 2006
Micro machining is an emerging technology with extremely large benefits and equally great challenges. The push to develop processes and tools capable of micro scale fabrication results from the widespread drive to reduce part and feature size in many industrial and commercial sectors.
Cox, Daniel J., Newby, Glynn, Park, Hyung Wook, Steven, Y. Liang, Liu, Wang-Lin, Hsieh, Shang-Bin, Hwang, Joon   +6 more
openaire   +1 more source

Machining strategy development in 5-axis milling operations using process models [PDF]

, 2010
Increased productivity and part quality can be achieved by selecting machining strategies and conditions properly. At one extreme very high speed and feed rate with small depth of cut can be used for high productivity whereas deep cuts accompanied with ...
Budak, Erhan, Murtezaoglu, Yavuz, Murtezaoğlu, Yavuz, Ozkirimli, Omer Mehmet, Ozturk, Erdem, Tunc, Taner L., Tunç, Taner L., Özkırımlı, Ömer Mehmet, Öztürk, Erdem   +8 more
core  

Residual Stresses in Machining of AISI 52100 Steel under Dry and Cryogenic Conditions: A Brief Summary [PDF]

, 2014
17th Conference on Material Forming (ESAFORM) - FinlandResidual stress is one of the most important surface integrity parameter that can significantly affect the service performance of a mechanical component, such as: contact fatigue, corrosion ...
BATISTA, Antonio, CARUSO, Serafino, OUTEIRO, José, UMBRELLO, Domenico   +3 more
core   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source