Results 61 to 70 of about 5,151,847 (295)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Study on Simulation Reliability Test of Machining Center

, 2010
Reliability research on machining center has great significance for the quality improvement of the machining center and its mechanical products. The long cycle and insufficient accuracy of collecting data is the main problem of the current reliability ...
Zhuo Wang, Jian Zhong Shang, Xiang Po Zhang   +2 more
core   +1 more source

Influence of pilot hole on cutting force during threading with wireless holder system

Journal of Advanced Mechanical Design, Systems, and Manufacturing
This paper examines the machining accuracy when simultaneously machining pilot holes and threads, and the machining accuracy when machining threads after pilot hole drilling.
Shota MATSUI, Nobutoshi OZAKI, Toshiki HIROGAKI, Eiichi AOYAMA, Ryo MATSUDA   +4 more
doaj   +1 more source

High precision manufacturing method of multi-thread worm wheel using 5-axis machining center

Nihon Kikai Gakkai ronbunshu, 2019
In recent years, the speeding up of a rotary table using a worm gear pair has been required. In order to perform the speeding up of a rotary table, the multi-thread worm wheel is adopted in some cases. When a hob tool for cutting a worm wheel is likewise
Shigenori HAMADA, Kazumasa KAWASAKI, Isamu TSUJI   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Thermal Characterization and Predictive Modeling of Thermo-Elastic Errors in Five-Axis Machining Centers Using Dynamic R-Test

Journal of Manufacturing and Materials Processing
Five-axis machining centers are essential for manufacturing complex, high-precision parts. However, their accuracy is significantly affected by thermally induced geometric errors, also known as thermo-elastic errors.
Tae Hun Lee, Tim Klinkhammer, Daniel Zontar, Christian Brecher   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Fabrication of magic-mirror with magnetic polishing and end-milling on machining center

Nihon Kikai Gakkai ronbunshu, 2014
Recently, with the fabrication of the magic-mirror having the micro C2-continuous surface, it is difficult to hand down magic-mirror fabrication technology, due to downsizing of veteran engineers or even their successors.
Tatsuya FURUKI, Lei MA, Toshiki HIROGAKI, Eiichi AOYAMA, Keiji OGAWA   +4 more
doaj   +1 more source

An eigenanalysis of data centering in machine learning

CoRR, 2014
Many pattern recognition methods rely on statistical information from centered data, with the eigenanalysis of an empirical central moment, such as the covariance matrix in principal component analysis (PCA), as well as partial least squares regression, canonical-correlation analysis and Fisher discriminant analysis. Recently, many researchers advocate
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source