Results 61 to 70 of about 13,240 (266)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Elucidation of the polishing mechanism by the magnetic polishing brush

Nihon Kikai Gakkai ronbunshu, 2016
Nowadays, a free-form surface, such as molding die surface, is required to be finished by reducing the environmental burden. Therefore, a novel polishing technology is needed with a less abrasive slurry,for the reduction of which a magnetic abrasive ...
Lei MA, Tatsuya FURUKI, Wei WU, Toshiki HIROGAKI, Eiichi AOYAMA   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Cooling of spindle shaft for machining center using heat exchangers

Journal of Advanced Mechanical Design, Systems, and Manufacturing
The cooling method for machining center spindles commonly involves utilizing a fixed-side jacket cooling system with lubricating oil or coolant as the refrigerant.
Shingo KAJIKAWA, Sho MORITA, Naohiko SUGITA   +2 more
doaj   +1 more source

An eigenanalysis of data centering in machine learning

CoRR, 2014
Many pattern recognition methods rely on statistical information from centered data, with the eigenanalysis of an empirical central moment, such as the covariance matrix in principal component analysis (PCA), as well as partial least squares regression, canonical-correlation analysis and Fisher discriminant analysis. Recently, many researchers advocate
openaire   +2 more sources

Coring on Ceramics by Machining Center.

Journal of the Japan Society for Precision Engineering, 1993
A diamond core drill has been well carried out in the ceramics drilling. In this investigation, a vertical type machining center (MC) was used in the coring of alumina ceramics with a metal bonded diamond core drill. To clarify the mechanism of coring, the influences of coring conditions on the coring force, grinding ratio, successive zone of coring ...
KITA, Yoshihiro, CHOI, Hwan, KAWAGUCHI, Itaru, NAKAO, Hiroshi, KITAGUCHI, Yoshiaki, TSUJI, Yoshihide   +5 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Motion error estimation of circular arc interpolation cutter path of machining center produced by NC linear acceleration/deceleration processing

Nihon Kikai Gakkai ronbunshu
From the machining center (MC) user’s point of view, this paper, as the second report of a systematic study, proposes a practical approach to estimate the trajectory error of a circular arc interpolation cutter path produced by the NC linear acceleration/
Hua QIU, Tetsurou YAMAGUCHI
doaj   +1 more source