Results 61 to 70 of about 12,418 (275)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Design of a pulse power supply unit for micro-ECM [PDF]

, 2014
Electrochemical micro-machining (μECM) requires a particular pulse power supply unit (PSU) to be developed in order to achieve desired machining performance. This paper summarises the development of a pulse PSU meeting the requirements of μECM. The pulse
A Muetze, AB Kamaraj, Alexandre Spieser, Atanas Ivanov, B Bhattacharyya, BJ Park, ES Lee, FM Ozkeskin, H Schulze, I Yang, J Kozak, J Kozak, JA McGeough, L Cagnon, L Yong, M Kock, MAH Mithu, MAH Mithu, R Mathew, R Schuster, S Burkert, SH Choi, SH Huang, T Tang, Y Liu, YJ Zhang, Z Zhang, Z Zhang, Z-W Fan   +28 more
core   +1 more source

Effect of Industrial Heat Treatment and Barrel Finishing on the Mechanical Performance of Ti6Al4V Processed by Selective Laser Melting [PDF]

, 2020
Additive manufacturing is now capable of delivering high-quality, complex-shaped metallic components. The titanium alloy Ti6Al4V is an example of a printable metal being broadly used for advanced structural applications.
Boschetto, Alberto, Bottini, Luana, Cortese, Luca, Nalli, Filippo, Veniali, Francesco   +4 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Experimental study of the brittle–ductile transition in hot cutting of SG iron specimens [PDF]

, 2013
http://www.sciencedirect.com/science/article/pii/S0924013612002579The present paper investigates the brittle-ductile transition (BDT) of the primary shear zone during cutting of spheroidal graphite (SG) iron in the austenitization temperature range ...
EL MANSORI, Mohamed, FOUILLAND-PAILLE, Laurence   +1 more
core   +6 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Experimental study of thin part vibration modes in machining [PDF]

, 2008
The machining of thin walls generally generates milling chatter, that damage surface roughness and manufacturing tools. Stability lobes which include natural frequencies are successful in case of tool chatter.
Arnaud, Lionel, Dessein, Gilles, Wehbe, Toufic   +2 more
core  

Influence of various process conditions on surface finishes induced by the direct metal deposition laser technique on a Ti–6Al–4V alloy [PDF]

, 2012
The direct metal deposition (DMD) with laser is a free-form metal deposition process for manufacturing dense pieces, which allows generating a prototype or small series of near net-shape structures. One of the most critical issues is that produced pieces
CARIN, Muriel, CARRON, Denis, FABBRO, Rémy, GHARBI, Myriam, GORNY, Cyril, LE MASSON, Philippe, MORVILLE, Simon, PEYRE, Patrice   +7 more
core   +6 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Displacements analysis of self-excited vibrations in turning

, 2009
The actual research deals with determining by a new protocol the necessary parameters considering a three-dimensional model to simulate in a realistic way the turning process on machine tool.
A Cowley, A Moufki, Alain Gérard, AV Dassanayake, C Mei, CF Bisu, CK Chen, Claudiu F. Bisu, DA Axinte, DE Dimla Sr, HE Merrit, I Marinescu, IN Tansel, JD Calderon-Najera, Jean-Yves K’nevez, K Liu, LZ Qiang, M Thomas, O Cahuc, O Cahuc, PG Benardos, Philippe Darnis, RL Kegg, W Grzeski, X Li, Y Sahin, YS Chiou   +26 more
core   +1 more source