Results 71 to 80 of about 2,309 (295)
Metals, 2020 Catastrophic shear instability is the dominant mechanism during orthogonal cutting of Ti6Al4V. Chip segmentation even at low speeds testifies to the emergence of some kind of instability during plastic deformation of the material.
Orestis Friderikos +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Local-to-Global Support Vector Machines (LGSVMs)
Pattern Recognition, 2022 For supervised classification tasks that involve a large number of instances, we propose and study a new efficient tool, namely the Local-to-Global Support Vector Machine (LGSVM) method. Its background some-how lies in the framework of approximation theory and of local kernel-based models, such as the Par-tition of Unity (PU) method.
Marchetti F., Perracchione E.
openaire +3 more sources
Precise vibrating electrochemical machining of a diamond-shaped hole with side-wall insulation [PDF]
, 2017 Electrochemical machining has the advantage of being free of cathode loss, thermal stress, and residual stress, and is suitable for high precision machining of metal structures.
Jianshe Zhao +5 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Learning the Localization Function: Machine Learning Approach to Fingerprinting Localization
CoRR, 2018 Considered as a data-driven approach, Fingerprinting Localization Solutions (FPSs) enjoy huge popularity due to their good performance and minimal environment information requirement. This papers addresses applications of artificial intelligence to solve two problems in Received Signal Strength Indicator (RSSI) based FPS, first the cumbersome training ...
Linchen Xiao +2 more
openaire +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Lazy Local Search Meets Machine Scheduling [PDF]
SIAM Journal on Computing, 2019 added 4 figures; sharpened the constant from 1+2/sqrt{5} to 17 ...
openaire +3 more sources