Results 91 to 100 of about 2,322 (298)
Experimental study of drilling white Calacatta–Carrara marble using artificial neural approach
Advances in Mechanical Engineering, 2019 Highly accurate marble processing is increasingly needed to comply with tight parametric/geometric tolerances and surface integrity specifications encountered while structuring, sculpture, and decorating.
Amira Abbassi +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Eudoxus: Characterizing and Accelerating Localization in Autonomous Machines
CoRR, 2020 We develop and commercialize autonomous machines, such as logistic robots and self-driving cars, around the globe. A critical challenge to our -- and any -- autonomous machine is accurate and efficient localization under resource constraints, which has fueled specialized localization accelerators recently. Prior acceleration efforts are point solutions
Yiming Gan +9 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Evaluation of localization systems for CNC machining of large FRPC parts [PDF]
, 2019 In machining of large fiber-reinforced polymer composite (FRPC) parts, the part must be precisely located before machining. The exact location and geometry are usually determined by the probing systems employing a touch probe integrated with a CNC ...
Selak, Luka, Bračun, Drago
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
On the chaotic nature of electro-discharge machining [PDF]
, 2015 The long-accepted thermoelectric model for electro-discharge machining is being brought into question. Several experimental facts prompt the proposal of a new theory based on the effect of gap pollution on the ignition of discharges.
Sofroniou, Mark +3 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Multi-point Clamping with Automatic Collision Avoidance for Aircraft Structural Parts Machining [PDF]
, 2016 In order to solve the problem of machining motion collision between cutter and fixtures, a multi-point clamping system with automatic collision avoidance is proposed for aircraft structural parts.
Hou, Bo +6 more
core +1 more source