Results 101 to 110 of about 2,322 (298)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Integrated Eddy Current Inspection in Turning Machines with Deployable Algorithms for Automated Defect Detection in Railway Wheels

Metals
Ensuring the structural integrity and service reliability of railway wheels has become a key challenge in modern manufacturing and maintenance strategies within the railway sector.
Jose Luis Lanzagorta, Julen Mendikute, Irati Sanchez, Paula Ruiz, Iratxe Aizpurua-Maestre, Jokin Munoa   +5 more
doaj   +1 more source

Quantitative robustness of localized support vector machines

Communications on Pure and Applied Analysis, 2020
The huge amount of available data nowadays is a challenge for kernel-based machine learning algorithms like SVMs with respect to runtime and storage capacities. Local approaches might help to relieve these issues and to improve statistical accuracy. It has already been shown that these local approaches are consistent and robust in a basic sense.
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A workpiece registration and localization adjustment method with contact inspection under multi-tolerance conditions [PDF]

, 2019
The workpiece contour errors from previous process affect current process. In order to improve workpiece allowance distribution, this article presents a workpiece registration and localization adjustment method with contact inspection.
Ding, Guofu, Han, Lei, Zou, Yisheng, Qin, Sheng-feng, Li, Yong, Jiang, Lei   +5 more
core   +1 more source

Jet Electrochemical Micromilling of Ti-6Al-4V Using NaCl–Ethylene Glycol Electrolyte

Micromachines
Titanium alloys are widely used in aerospace and biomedicine because of their excellent mechanical characteristics, but these properties also make such alloys difficult to cut.
Shen Niu, Kaiqiang Huang, Pingmei Ming, Siru Wang, Fei Zhao, Ge Qin, Huan Liu   +6 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

On the hybrid localization/envelopment problem [PDF]

, 1999
The problem of aligning the CAD model of a workpiece such that all points measured on the finished surfaces of the workpiece match closely to corresponding surfaces on the model while all unmachined surfaces lie outside the model is referred to as the ...
Li, Z. X., Chu, Y. X., Gou, J. B.
core   +1 more source