Results 121 to 130 of about 2,309 (295)

Local Edge Machine (Lem)

, 2016
Local Edge Machine (LEM) Beginning with time-series gene expression data, the Local Edge Machine (LEM) seeks to find functional network models capable of exhibiting the dynamic behavior of the data. It combines nonlinear kinetic equations, a Bayesian framework, and a local approximation to the system of differential equations that relies on sparse ...
Guo, Xin, McGoff, Kevin, Deckard, Anastasia, Harer, John   +3 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Research on jet electrochemical machining with coaxial megasonic assistance

Ultrasonics Sonochemistry
In order to address the problem of poor localization in electrochemical machining (ECM), a coaxial megasonic assisted jet ECM method was proposed. Based on theoretical analysis, experiments were conducted to compare the effects of various electrolyte ...
Ke Zhai, Yongkang Liang, Tengnan Li, Shihao Ma, Liqun Du   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Adaptive Robotic Deburring of Molded Parts via 3D Vision and Tolerance-Constrained Non-Rigid Registration

Journal of Manufacturing and Materials Processing
This paper introduces an innovative automatic trajectory generation method for the robotic deburring of molded parts, effectively addressing challenges posed by burr defects and workpiece deformation common in casting and injection molding processes ...
Zuping Zhou, Zhilin Sun, Pengfei Luo
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Elevated-Temperature Tensile Behavior and Properties of Inconel 718 Fabricated by In-Envelope Additive–Subtractive Hybrid Manufacturing and Post-Process Precipitation Hardening

Journal of Manufacturing and Materials Processing
The present study focuses on advancing one of the most popular AM techniques, namely, laser powder bed fusion (LPBF) technology, which has the ability to produce complex geometry parts with minimum material waste but continues to face challenges in ...
Sheida Sarafan, Priti Wanjara, Roger Pelletier, Sila Ece Atabay, Javad Gholipour, Josh Soost, Robert Amos, Prakash Patnaik   +7 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Segmentation and shear localization when turning TiMMC (Titanium Metal Matrix Composites) [PDF]

, 2011
Titanium Metal Matrix Composite (TiMMC) is a new class of material, which has a high potential in industrial applications. The TiC ceramic particles in the titanium matrix improve its physical properties; however they also cause high abrasive wear of the
Attia, H., Balazinski, Marek, Balazinski, M., Bejjani, R., Aramesh, M., Kishawy, H.   +5 more
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source