Results 121 to 130 of about 2,322 (298)

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Through-mask electrochemical machining of micro-dimple arrays with synchronization of power switching and cathode movements

Advances in Mechanical Engineering
Micro-dimple arrays with specific shapes and dimensions are crucial for reducing wear and vibration. Through-mask electrochemical machining (TMECM) using flexible cathodes removes materials based on anodic dissolution and allows for efficient processing ...
Feng Wang, Xinke Yuan, Tao Wang, Yiqing Wan, Yafeng He, Min Kang   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Development of an energy consumption map for turning inconel 718 through coupled chip-morphology and material-deformation analysis

Scientific Reports
Sustainable machining of Inconel 718, a nickel-based superalloy that is highly valuable in aerospace, is faced with the challenge that it has high energy requirements and poor machinability. In this study, a new energy consumption map and combined energy-
Muhammad Adnan Khan, Riaz Ahmad, Muhammad Rizwan ul Haq, Syed Husain Imran Jaffery, Danyal Zahid   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Research on jet electrochemical machining with coaxial megasonic assistance

Ultrasonics Sonochemistry
In order to address the problem of poor localization in electrochemical machining (ECM), a coaxial megasonic assisted jet ECM method was proposed. Based on theoretical analysis, experiments were conducted to compare the effects of various electrolyte ...
Ke Zhai, Yongkang Liang, Tengnan Li, Shihao Ma, Liqun Du   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Adaptive Robotic Deburring of Molded Parts via 3D Vision and Tolerance-Constrained Non-Rigid Registration

Journal of Manufacturing and Materials Processing
This paper introduces an innovative automatic trajectory generation method for the robotic deburring of molded parts, effectively addressing challenges posed by burr defects and workpiece deformation common in casting and injection molding processes ...
Zuping Zhou, Zhilin Sun, Pengfei Luo
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Elevated-Temperature Tensile Behavior and Properties of Inconel 718 Fabricated by In-Envelope Additive–Subtractive Hybrid Manufacturing and Post-Process Precipitation Hardening

Journal of Manufacturing and Materials Processing
The present study focuses on advancing one of the most popular AM techniques, namely, laser powder bed fusion (LPBF) technology, which has the ability to produce complex geometry parts with minimum material waste but continues to face challenges in ...
Sheida Sarafan, Priti Wanjara, Roger Pelletier, Sila Ece Atabay, Javad Gholipour, Josh Soost, Robert Amos, Prakash Patnaik   +7 more
doaj   +1 more source