Results 111 to 120 of about 2,322 (298)
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Evaluation criteria adequacy of process localization of anodic dissolution using wire cylindrical electrodes [PDF]
, 2016 Стаття присвячена розробці науково обґрунтованих методів оцінювання локалізації процесу анодного розчинення в електрохімічній комірці з циліндричним електродом. Проведено аналіз можливості застосування відомих підходів до оцінювання локалізації процесу
Осипенко, Василь Іванович +2 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Mechanics of machining zirconium-based bulk metallic glass [PDF]
, 2021 Bulk Metallic Glasses (BMGs) are amorphous metal alloys with applications in biomedicine, electronics, sports equipment, and aerospace. In the machining of BMGs, inhomogeneous deformation and shear localization occur, which are influenced by the ...
Maroju, Naresh Kumar
core
, 2016 Local Edge Machine (LEM) Beginning with time-series gene expression data, the Local Edge Machine (LEM) seeks to find functional network models capable of exhibiting the dynamic behavior of the data. It combines nonlinear kinetic equations, a Bayesian framework, and a local approximation to the system of differential equations that relies on sparse ...
Guo, Xin +3 more
openaire +2 more sources
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
An integrated setup for sequential hybrid Laser Beam Micromachining (LBMM) and Micro‑EDM for Machining Micro‑hole arrays with automated tool localization [PDF]
Micro holes array has significant applications in the field of aerospace and turbo machinery, industrial filtration, microfluidic devices, biomedical engineering, and so on. There are various ways to manufacture micro holes arrays.
Saleh, Tanveer, Wan Azhar, Wan Ahmad
core +1 more source