Results 51 to 60 of about 2,247 (260)
Adiabatic Shear Banding in Nickel and Nickel-Based Superalloys: A Review
Metals, 2022 This review paper discusses the formation and propagation of adiabatic shear bands in nickel-based superalloys. The formation of adiabatic shear bands (ASBs) is a unique dynamic phenomenon that typically precedes catastrophic, unpredicted failure in many
Russell A. Rowe +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Metals, 2021 The field of applied wire electrical discharge machining (WEDM) is rapidly expanding due to rapidly increasing demand for parts made of hard-to-machine materials.
Sergey N. Grigoriev +7 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Learning the Localization Function: Machine Learning Approach to Fingerprinting Localization
CoRR, 2018 Considered as a data-driven approach, Fingerprinting Localization Solutions (FPSs) enjoy huge popularity due to their good performance and minimal environment information requirement. This papers addresses applications of artificial intelligence to solve two problems in Received Signal Strength Indicator (RSSI) based FPS, first the cumbersome training ...
Linchen Xiao +2 more
openaire +3 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
A machine learning approach for localization in cellular environments [PDF]
2018 IEEE/ION Position, Location and Navigation Symposium (PLANS), 2018 A machine learning approach is developed for localization based on received signal strength (RSS) from cellular towers. The proposed approach only assumes knowledge of RSS fingerprints of the environment, and does not require knowledge of the cellular base transceiver station (BTS) locations, nor uses any RSS mathematical model.
Ali A. Abdallah +2 more
openaire +3 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source